ethyl 5-acetyl-6-hydroxy-6-methyl-1-(2-methylphenyl)-2-oxo-4-phenylpiperidine-3-carboxylate | 1430745-30-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: ethyl 5-acetyl-6-hydroxy-6-methyl-1-(2-methylphenyl)-2-oxo-4-phenylpiperidine-3-carboxylate
• 英文别名: Ethyl 5-acetyl-6-hydroxy-6-methyl-1-(2-methylphenyl)-2-oxo-4-phenylpiperidine-3-carboxylate
• CAS: 1430745-30-4
• 化学式: C₂₄H₂₇NO₅
• 分子量: 409.482
• InChiKey: RCJPMCWOUHLPIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  83.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-(2-甲基苯胺基)-3-氧代丙酸乙酯 、 3-亚苄基-2,4-戊二酮 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以90%的产率得到ethyl 5-acetyl-6-hydroxy-6-methyl-1-(2-methylphenyl)-2-oxo-4-phenylpiperidine-3-carboxylate
  参考文献：
  名称：

  Synthesis of ethyl 5-acetyl-1-R-4-aryl-6-hydroxy-6-methyl-2-oxopiperidine-3-carboxylates

  摘要：

  The reaction of arylidene acetylacetones and ethoxycarbonylacetamides in the presence of triethyl-amine was found to lead to the formation of ethyl 5-acetyl-1-R-4-aryl-6-hydroxy-6-methyl-2-oxo-piperidine-3-carboxylates.

  DOI：

  10.1007/s10593-013-1212-6

文献信息

• Synthesis of ethyl 5-acetyl-1-R-4-aryl-6-hydroxy-6-methyl-2-oxopiperidine-3-carboxylates
  作者：M. S. Sargsyan、S. S. Hayotsyan、A. Kh. Khachatryan、A. E. Badasyan、G. A. Panosyan、S. G. Kon’kova

  DOI：10.1007/s10593-013-1212-6

  日期：2013.3

  The reaction of arylidene acetylacetones and ethoxycarbonylacetamides in the presence of triethyl-amine was found to lead to the formation of ethyl 5-acetyl-1-R-4-aryl-6-hydroxy-6-methyl-2-oxo-piperidine-3-carboxylates.