methyl (2S)-4-methyl-2-[[2-naphthalen-1-yl-4-[[(1-tritylimidazol-4-yl)methylamino]methyl]benzoyl]amino]pentanoate | 1027488-86-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: methyl (2S)-4-methyl-2-[[2-naphthalen-1-yl-4-[[(1-tritylimidazol-4-yl)methylamino]methyl]benzoyl]amino]pentanoate
• CAS: 1027488-86-3
• 化学式: C₄₈H₄₆N₄O₃
• 分子量: 726.918
• InChiKey: WJFCULZKHYPPOZ-GWHBCOKCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.5
• 重原子数：
  55
• 可旋转键数：
  15
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  85.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl (2S)-4-methyl-2-[[2-naphthalen-1-yl-4-[[(1-tritylimidazol-4-yl)methylamino]methyl]benzoyl]amino]pentanoate 在 三乙基硅烷 、 sodium hydroxide 、 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 1.5h， 生成 N-[4-(Imidazol4-ylmethylaminomethyl)-2-naphth-1-ylbenzoyl]leucine
  参考文献：
  名称：

  Potent, Highly Selective, and Non-Thiol Inhibitors of Protein Geranylgeranyltransferase-I

  摘要：

  The design, synthesis, and biological evaluation of a family of peptidomimetic inhibitors of protein geranylgeranyltransferase-I (PGGTase-I) are reported. The inhibitors are based on the C-terminal CAAL sequence of many geranylgeranylated proteins. Using 2-aryl-4-aminobenzoic acid derivatives as mimetics for the central dipeptide (AA), we have attached a series of imidazole and pyridine derivatives to the N-terminus as cysteine replacements. These non-thiol-containing peptidomimetics show exceptional selectivity for PGGTase-I over the closely related enzyme protein farnesyltransferase (PFTase). This selectivity is retained in whole cells where the inhibitors were shown to block the geranylgeranylation of Rap-1A without affecting the farnesylation of small GTP-binding proteins such as Ras.

  DOI：

  10.1021/jm9900873
• 作为产物：
  描述：

  methyl 4-iodo-2-(1-naphthyl)benzoate 在 titanium(IV) isopropylate 、 lithium hydroxide 、 sodium tetrahydroborate 、 四(三苯基膦)钯 、 sodium cyanoborohydride 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 cobalt(II) chloride 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 28.0h， 生成 methyl (2S)-4-methyl-2-[[2-naphthalen-1-yl-4-[[(1-tritylimidazol-4-yl)methylamino]methyl]benzoyl]amino]pentanoate
  参考文献：
  名称：

  Potent, Highly Selective, and Non-Thiol Inhibitors of Protein Geranylgeranyltransferase-I

  摘要：

  The design, synthesis, and biological evaluation of a family of peptidomimetic inhibitors of protein geranylgeranyltransferase-I (PGGTase-I) are reported. The inhibitors are based on the C-terminal CAAL sequence of many geranylgeranylated proteins. Using 2-aryl-4-aminobenzoic acid derivatives as mimetics for the central dipeptide (AA), we have attached a series of imidazole and pyridine derivatives to the N-terminus as cysteine replacements. These non-thiol-containing peptidomimetics show exceptional selectivity for PGGTase-I over the closely related enzyme protein farnesyltransferase (PFTase). This selectivity is retained in whole cells where the inhibitors were shown to block the geranylgeranylation of Rap-1A without affecting the farnesylation of small GTP-binding proteins such as Ras.

  DOI：

  10.1021/jm9900873

文献信息

• Potent, Highly Selective, and Non-Thiol Inhibitors of Protein Geranylgeranyltransferase-I
  作者：Anil Vasudevan、Yimin Qian、Andreas Vogt、Michelle A. Blaskovich、Junko Ohkanda、Said M. Sebti、Andrew D. Hamilton

  DOI：10.1021/jm9900873

  日期：1999.4.22

  The design, synthesis, and biological evaluation of a family of peptidomimetic inhibitors of protein geranylgeranyltransferase-I (PGGTase-I) are reported. The inhibitors are based on the C-terminal CAAL sequence of many geranylgeranylated proteins. Using 2-aryl-4-aminobenzoic acid derivatives as mimetics for the central dipeptide (AA), we have attached a series of imidazole and pyridine derivatives to the N-terminus as cysteine replacements. These non-thiol-containing peptidomimetics show exceptional selectivity for PGGTase-I over the closely related enzyme protein farnesyltransferase (PFTase). This selectivity is retained in whole cells where the inhibitors were shown to block the geranylgeranylation of Rap-1A without affecting the farnesylation of small GTP-binding proteins such as Ras.