2-[4-(4-amino-2-fluoro-phenyl)-piperazin-1-yl]-N,N-diethyl-2-phenyl-acetamide | 935854-67-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[4-(4-amino-2-fluoro-phenyl)-piperazin-1-yl]-N,N-diethyl-2-phenyl-acetamide
• 英文别名: 2-[4-(4-amino-2-fluorophenyl)piperazin-1-yl]-N,N-diethyl-2-phenylacetamide
• CAS: 935854-67-4
• 化学式: C₂₂H₂₉FN₄O
• 分子量: 384.497
• InChiKey: GEMDONYQNICUCU-UHFFFAOYSA-N

物化性质

• 沸点：
  552.8±50.0 °C(Predicted)
• 密度：
  1.182±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  52.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-[4-(4-amino-2-fluoro-phenyl)-piperazin-1-yl]-N,N-diethyl-2-phenyl-acetamide 在 水 、 tin(ll) chloride 、 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 1.5h， 以36%的产率得到[4-(4-amino-2-chloro-phenyl)-piperazin-1-yl]-phenyl-acetic acid methyl ester
  参考文献：
  名称：

  SUBSTITUTED PIPERAZINES AND PIPERIDINES AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR

  摘要：

  这项发明提供了新型的非肽类NPY Y2受体抑制剂，可用于治疗或预防：抗焦虑障碍或抑郁症；受损的哺乳动物神经组织；通过给予神经营养因子进行治疗的疾病；神经系统疾病；骨质流失；与物质相关的障碍；睡眠/清醒障碍；心血管疾病；肥胖症；或与肥胖相关的疾病。该发明的化合物还可用于调节内分泌功能，特别是垂体和下丘脑腺控制的内分泌功能，并因此可用于治疗或预防排卵障碍和不孕症。

  公开号：

  US20070100141A1
• 作为产物：
  描述：

  2-[4-(4-nitro-2-fluoro-phenyl)-piperazin-1-yl]-N,N-diethyl-2-phenyl-acetamide 在 水 、 tin(ll) chloride 、 碳酸氢钠 作用下， 以 乙醇 、 乙酸乙酯 、 水 为溶剂， 反应 16.0h， 生成 2-[4-(4-amino-2-fluoro-phenyl)-piperazin-1-yl]-N,N-diethyl-2-phenyl-acetamide
  参考文献：
  名称：

  SUBSTITUTED PIPERAZINES AND PIPERIDINES AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR

  摘要：

  这项发明提供了新型的非肽类NPY Y2受体抑制剂，可用于治疗或预防：抗焦虑障碍或抑郁症；受损的哺乳动物神经组织；通过给予神经营养因子进行治疗的疾病；神经系统疾病；骨质流失；与物质相关的障碍；睡眠/清醒障碍；心血管疾病；肥胖症；或与肥胖相关的疾病。该发明的化合物还可用于调节内分泌功能，特别是垂体和下丘脑腺控制的内分泌功能，并因此可用于治疗或预防排卵障碍和不孕症。

  公开号：

  US20070100141A1

文献信息

• PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR
  申请人：Dvorak Curt A.

  公开号：US20110046151A1

  公开（公告）日：2011-02-24

  The present invention is directed to piperazinyl derivatives useful as inhibitors of the NPY Y2 receptor, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds for the treatment and/or prevention of disorders, diseases and conditions mediated by the NPY Y2 receptor.

  本发明涉及对哌嗪基衍生物的使用，作为NPY Y2受体的抑制剂，包括该化合物的制药组合物，制备该化合物的过程以及利用该化合物治疗和/或预防由NPY Y2受体介导的疾病、疾病和病症的用途。
• Substituted piperazines and piperidines as modulators of the neuropeptide Y2 receptor
  申请人：Janssen Pharmaceutica NV

  公开号：US08183239B2

  公开（公告）日：2012-05-22

  The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; sleep/wake disorders; cardiovascular disease; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility. The compounds of the present invention are of the formula where Ring T is a heterocycloalkyl ring selected from the group consisting of:

  该发明提供了一种新型的非肽类NPY Y2受体抑制剂，可用于治疗或预防：抗焦虑障碍或抑郁症；受损哺乳动物神经组织；通过神经营养因子的给药治疗反应性疾病；神经系统疾病；骨质流失；与物质相关的疾病；睡眠/清醒障碍；心血管疾病；肥胖症；或肥胖相关疾病。本发明的化合物还可用于调节内分泌功能，尤其是垂体和下丘脑腺体控制的内分泌功能，并因此可用于治疗或预防无排卵和不孕症。本发明的化合物的结构式如下：其中Ring T是从以下群组中选择的杂环烷基环：
• Piperazinyl derivatives useful as modulators of the neuropeptide Y2 receptor
  申请人：Janssen Pharmaceutica NV

  公开号：US08338426B2

  公开（公告）日：2012-12-25

  The present invention is directed to piperazinyl derivatives useful as inhibitors of the NPY Y2 receptor, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds for the treatment and/or prevention of disorders, diseases and conditions mediated by the NPY Y2 receptor.

  本发明涉及对吡哌啶衍生物的使用，作为NPY Y2受体的抑制剂，包括所述化合物的制药组合物，制备所述化合物的过程以及使用所述化合物治疗和/或预防由NPY Y2受体介导的疾病、疾病和状况。
• Efficient ¹¹C-Carbonylation of Isolated Aryl Palladium Complexes for PET: Application to Challenging Radiopharmaceutical Synthesis
  作者：Thomas L. Andersen、Stig D. Friis、Hélène Audrain、Patrik Nordeman、Gunnar Antoni、Troels Skrydstrup

  DOI：10.1021/ja511441u

  日期：2015.2.4

  We describe the successful implementation of palladium-aryl oxidative addition complexes as stoichiometric reagents in carbonylation reactions with (CO)-C-11 to produce structurally challenging, pharmaceutically relevant compounds. This method enables the first C-11-carbonyl labeling of an approved PET tracer, [C-11]raclopride, for the dopamine D2/D3 receptor by carbonylation with excellent radiochemical purity and yield. Two other molecules, [C-11]olaparib and [C-11]JNJ 31020028, were efficiently labeled in this manner. The technique distinguishes itself from existing methods by the markedly improved purity profiles of the tracer molecules produced and provides access to complex structures in synthetically useful yields, hereby offering a viable alternative to other C-11-labeling strategies.
• US8183239B2
  申请人：——

  公开号：US8183239B2

  公开（公告）日：2012-05-22