5'-(4,4'-dimethoxytrityl)-5-(3-trifluoracetylaminopropenyl)-2'-deoxyuridine | 96102-25-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5'-(4,4'-dimethoxytrityl)-5-(3-trifluoracetylaminopropenyl)-2'-deoxyuridine
• 英文别名: N-[3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]prop-2-enyl]-2,2,2-trifluoroacetamide
• CAS: 96102-25-9
• 化学式: C₃₅H₃₄F₃N₃O₈
• 分子量: 681.665
• InChiKey: DJJQNJQSPYAYPU-FRXPANAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  49
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  136
• 氢给体数：
  3
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  5'-(4,4'-dimethoxytrityl)-5-(3-trifluoracetylaminopropenyl)-2'-deoxyuridine 在 咪唑 、 对甲苯磺酸 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  [EN] CLEAVABLE CYCLIC LOOP NUCLEOTIDES FOR NANOPORE SEQUENCING
  [FR] NUCLÉOTIDES À BOUCLE CYCLIQUE CLIVABLES POUR SÉQUENÇAGE DE NANOPORES

  摘要：

  In one aspect, the disclosed technology relates to nanopore sequencing with a polynucleotide comprising a plurality of nucleotides, wherein each nucleotide comprises a linker construct between two positions of the nucleotide, wherein the linker construct optionally comprises a reporter moiety corresponding to the identity of the nucleotide, and wherein the linker construct is a part of the cleavable cyclic loop nucleotide comprising a cleavable site. In some embodiments, the nucleotides further comprise arresting constructs for slowing or halting the polynucleotide translocation through a nanopore.

  公开号：

  WO2023215506A1
• 作为产物：
  描述：

  5-(3'-trifluoroacetamidoallyl)-2'-deoxyuridine 、 4,4'-双甲氧基三苯甲基氯 在 吡啶 作用下， 反应 5.0h， 以74%的产率得到5'-(4,4'-dimethoxytrityl)-5-(3-trifluoracetylaminopropenyl)-2'-deoxyuridine
  参考文献：
  名称：

  [EN] A SYSTEM FOR DELIVERING THERAPEUTIC AGENTS INTO LIVING CELLS AND CELL NUCLEI
  [FR] SYSTEME POUR INTRODUIRE DES AGENTS THERAPEUTIQUES DANS DES CELLULES VIVANTES ET NOYAUX DE CELLULE

  摘要：

  公开号：

  WO2006010084A3

文献信息

• [EN] A SYSTEM FOR DELIVERING THERAPEUTIC AGENTS INTO LIVING CELLS AND CELL NUCLEI<br/>[FR] SYSTEME POUR INTRODUIRE DES AGENTS THERAPEUTIQUES DANS DES CELLULES VIVANTES ET NOYAUX DE CELLULE
  申请人：SEGEV DAVID

  公开号：WO2006010084A3

  公开（公告）日：2006-04-27
• Design and synthesis of dinucleotide 5′-triphosphates with expanded functionality
  作者：Tatiana V. Abramova、Svetlana V. Vasileva、Ludmila S. Koroleva、Nina S. Kasatkina、Vladimir N. Silnikov

  DOI：10.1016/j.bmc.2008.09.029

  日期：2008.10

  We propose the new approach to the synthesis of 5 '-triphosphate derivatives of natural and modified dinucleotides with expanded functionality. Our strategy includes the combination of the solution phase synthesis of necessary dimers using the wide range of nucleic acids chemistry methods and the subsequent introduction of the triphosphate residue. A number of the new potential substrates for the template dependent synthesis of nucleic acids with expanded functionality are obtained, namely, 5 '-triphosphates of dinucleotides containing the functionally active groups in heterocyclic bases, in carbohydrate -phosphate backbone, and the groups mimicking the residues of natural amino acids. The abilities of the proposed synthetic route are also demonstrated by the synthesis of 5 '-triphosphates of dinucleotides with modified carbohydrate-phosphate backbone. (C) 2008 Elsevier Ltd. All rights reserved.
• [EN] CLEAVABLE CYCLIC LOOP NUCLEOTIDES FOR NANOPORE SEQUENCING<br/>[FR] NUCLÉOTIDES À BOUCLE CYCLIQUE CLIVABLES POUR SÉQUENÇAGE DE NANOPORES
  申请人：[en]ILLUMINA, INC.

  公开号：WO2023215506A1

  公开（公告）日：2023-11-09

  In one aspect, the disclosed technology relates to nanopore sequencing with a polynucleotide comprising a plurality of nucleotides, wherein each nucleotide comprises a linker construct between two positions of the nucleotide, wherein the linker construct optionally comprises a reporter moiety corresponding to the identity of the nucleotide, and wherein the linker construct is a part of the cleavable cyclic loop nucleotide comprising a cleavable site. In some embodiments, the nucleotides further comprise arresting constructs for slowing or halting the polynucleotide translocation through a nanopore.