N-(5-bromopyridin-3-yl)-1-methylpiperidine-4-carboxamide | 1314734-62-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(5-bromopyridin-3-yl)-1-methylpiperidine-4-carboxamide
• CAS: 1314734-62-7
• 化学式: C₁₂H₁₆BrN₃O
• 分子量: 298.183
• InChiKey: ILVQIAPLROOAAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  45.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-溴-3-氨基吡啶 、 1-甲基哌啶-4-甲酸 在 草酰氯 、 N,N-二甲基甲酰胺 、 吡啶 、 碳酸氢钠 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 3.5h， 以43%的产率得到N-(5-bromopyridin-3-yl)-1-methylpiperidine-4-carboxamide
  参考文献：
  名称：

  [EN] 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF
  [FR] 1H-PYRAZOLO[3,4-B]PYRIDINES ET LEURS UTILISATIONS THÉRAPEUTIQUES

  摘要：

  本文提供了按照式（I）的化合物及其药用盐，以及包含它们的组合物，用于各种方法，包括治疗结肠癌、卵巢癌、胰腺癌、乳腺癌、肝癌、前列腺癌和血液系统肿瘤。

  公开号：

  WO2011084486A1

文献信息

• INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF
  申请人：SAMUMED, LLC

  公开号：US20130267495A1

  公开（公告）日：2013-10-10

  Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

  揭示了用于治疗各种疾病和病理的吲唑化合物。更具体地，本发明涉及使用吲唑化合物或其类似物治疗由Wnt途径信号激活所特征化的疾病（例如癌症、异常细胞增殖、血管生成、阿尔茨海默病、肺病和骨关节炎）、调节由Wnt途径信号介导的细胞事件，以及由于Wnt途径和/或一个或多个Wnt信号组分的突变或失调而引起的遗传疾病和神经系统疾病/疾患。还提供了治疗与Wnt相关疾病状态的方法。
• [EN] INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF<br/>[FR] INHIBITEURS D'INDAZOLE DU TRAJET DE SIGNAL DE WNT ET LEURS UTILISATIONS THÉRAPEUTIQUES
  申请人：SAMUMED LLC

  公开号：WO2013151708A1

  公开（公告）日：2013-10-10

  Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states. One embodiment disclosed herein includes a compound having the structure of Formula I:

  本发明揭示了用于治疗各种疾病和病理的吲唑化合物。更具体地，本发明涉及使用吲唑化合物或其类似物治疗由Wnt通路信号激活引起的障碍（例如癌症、异常细胞增殖、血管生成、阿尔茨海默病、肺部疾病和骨关节炎），调节由Wnt通路信号介导的细胞事件，以及由于Wnt通路和/或一个或多个Wnt信号传递组分的突变或失调而引起的遗传疾病和神经状况/紊乱/疾病。还提供了治疗Wnt相关疾病状态的方法。本文所披露的一种实施例包括具有式I结构的化合物：
• 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF
  申请人：Hood John

  公开号：US20110190290A1

  公开（公告）日：2011-08-04

  Provided herein are compounds according to Formula I and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancers such as colon, ovarian, pancreatic, breast, liver, prostate and hematologic cancers:

  本文提供符合I式的化合物及其药学上可接受的盐，以及包含它们的组合物，用于各种方法，包括治疗结肠癌、卵巢癌、胰腺癌、乳腺癌、肝癌、前列腺癌和血液学癌症。
• 1H-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
  申请人：Samumed, LLC

  公开号：US09067939B2

  公开（公告）日：2015-06-30

  Provided herein are compounds according to Formula I and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancers such as colon, ovarian, pancreatic, breast, liver, prostate and hematologic cancers:

  本文提供了按照公式I和其药学上可接受的盐所得到的化合物，以及包含这些化合物的组合物，用于各种方法，包括治疗结肠癌、卵巢癌、胰腺癌、乳腺癌、肝癌、前列腺癌和血液学癌症。
• 1H-pyrazolo[3,4-B]pyridines and therapeutic uses thereof
  申请人：Samumed, LLC

  公开号：US08815897B2

  公开（公告）日：2014-08-26

  Provided herein are compounds according to Formula I and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancers such as colon, ovarian, pancreatic, breast, liver, prostate and hematologic cancers:

  本文提供了按照公式I和其药学上可接受的盐所构成的化合物，以及包含它们的组合物，用于各种方法，包括用于治疗结肠、卵巢、胰腺、乳腺、肝脏、前列腺和血液系统恶性肿瘤：