2-甲基-2-(4-甲基-1-哌嗪)-丙胺 | 21404-92-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 2-甲基-2-(4-甲基-1-哌嗪)-丙胺
• 英文名称: 2-methyl-2-(4-methylpiperazin-1-yl)propan-1-amine
• 英文别名: 2-(4-Methyl-piperazino)-2-methyl-propylamin；2-methyl-2-(4-methyl-piperazin-1-yl)-propylamine
• CAS: 21404-92-2
• 化学式: C₉H₂₁N₃
• mdl: MFCD05201608
• 分子量: 171.286
• InChiKey: IHYRJCIGQGABMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933599090

反应信息

• 作为反应物：
  描述：

  2-甲基-2-(4-甲基-1-哌嗪)-丙胺 、 N,N’-bis{4-[(2-chIorobenzoyl)amino]phenyl}-5,10-dioxo-5H,10H-diimidazo[1,5-a:1',5'-d]pyrazine-1,6-dicarboxamide 在 N,N-二异丙基乙胺 作用下， 反应 19.0h， 以43 mg的产率得到N4-{4-[(2-chlorobenzoyl)amino]phenyl}-N5-[2-methyl-2-(4-methylpiperazin-1-yl)propyl]-1H-imidazole-4,5-dicarboxamide
  参考文献：
  名称：

  [EN] AMIDO-SUBSTITUTED AZOLE COMPOUNDS AS INHIBITORS OF TNKS1 AND/OR TNKS2
  [FR] COMPOSÉS AZOLE AMIDO-SUBSTITUÉS

  摘要：

  公开号：

  WO2015150449A3

文献信息

• Catalytic Enantioselective Protonation of Nitronates Utilizing an Organocatalyst Chiral Only at Sulfur
  作者：Kyle L. Kimmel、Jimmie D. Weaver、Melissa Lee、Jonathan A. Ellman

  DOI：10.1021/ja3026196

  日期：2012.6.6

  highly enantioselective protonation of nitronates formed upon the addition of α-substituted Meldrum's acids to terminally unsubstituted nitroalkenes is described. This work represents the first enantioselective catalytic addition of any type of nucleophile to this class of nitroalkenes. Moreover, for the successful implementation of this method, a new type of N-sulfinyl urea catalyst with chirality residing

  描述了在将 α-取代的 Meldrum 酸添加到末端未取代的硝基烯烃时形成的硝基的高度对映选择性质子化。这项工作代表了任何类型的亲核试剂对此类硝基烯烃的首次对映选择性催化加成。此外，为了成功实施该方法，开发了一种仅在亚磺酰基上具有手性的新型 N-亚磺酰基脲催化剂，从而能够引入多种非手性二胺基序。最后，Meldrum 的酸加成产物很容易以高产率转化为药学相关的 3,5-二取代吡咯烷酮。
• 6-(4-Hydroxy-phenyl)-3-alkyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
  申请人：SANOFI

  公开号：US20130085128A1

  公开（公告）日：2013-04-04

  The present invention relates to pyrazolo[3,4-b]pyridine compounds of the formula I, in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are defined as indicated below. The compounds of the formula I are kinase inhibitors, and are useful for the treatment of diseases associated with diabetes and diabetic complications, such as, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy, for example. The invention furthermore relates to the use of compounds of the formula I, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

  本发明涉及式I的吡唑并[3,4-b]吡啶化合物，其中R1、R2、R3、R4、R5、R6和R7如下所示。式I的化合物是激酶抑制剂，适用于治疗与糖尿病及糖尿病并发症相关的疾病，如糖尿病肾病、糖尿病神经病变和糖尿病视网膜病变等。此外，本发明还涉及式I的化合物的用途，特别是作为药物中的活性成分以及包含它们的药物组合物。
• Process for the preparation of polyisocyanurate dispersions modified with halogenated alcohols and compositions prepared therefrom
  申请人：BASF WYANDOTTE CORPORATION

  公开号：EP0056582A1

  公开（公告）日：1982-07-28

  Polyisocyanurate polymers are prepared by polymerization of polyisocyanates in organic solvents employing trimerization catalysts. The polyisocyanates are reacted with halogenated alcohols subsequent to polymerization. These polymers may be dispersed in polyols for the preparation of cellular and non-cellular polyurethane products having improved flame retardant physical properties.

  多异氰酸酯聚合物是通过使用三聚催化剂在有机溶剂中聚合多异氰酸酯制备而成。聚合后，多异氰酸酯会与卤化醇发生反应。这些聚合物可分散在多元醇中，用于制备具有更佳阻燃物理特性的蜂窝状和非蜂窝状聚氨酯产品。
• Process for the preparation of polyisocyanurate dispersions and compositions prepared therefrom
  申请人：BASF WYANDOTTE CORPORATION

  公开号：EP0056581A1

  公开（公告）日：1982-07-28

  Polyisocyanurate polymers are prepared by polymerization of polyisocyanates in organic solvents employing trimerization catalysts. The polyisocyanates are reacted with monofunctional active hydrogen compounds prior to polymerization or subsequent to the polymerization. These polymers may be dispersed in polyols for the preparation of cellular and non-cellular polyurethane products having improved physical properties.

  多异氰酸酯聚合物是通过多异氰酸酯在有机溶剂中利用三聚催化剂进行聚合反应制备的。聚合前或聚合后，多异氰酸酯会与单官能团活性氢化合物发生反应。这些聚合物可分散在多元醇中，用于制备具有更好物理性能的蜂窝状和非蜂窝状聚氨酯产品。
• Isocyanurate-modified polymethylene polyphenylene polyisocyanate compositions
  申请人：BASF Wyandotte Corporation

  公开号：EP0081710A1

  公开（公告）日：1983-06-22

  A stable isocyanurate-modified polyisocyanate prepared by trimerizing an organic polyisocyanate mixture of 45 to 70 percent by weight of diphenylmethane diisocyanate having an isomer mixture of 40 to 100 weight percent, 4,4'-, 0 to 50 weight percent 2,4-, and 0 to 10 weight percent 2,2'-diphenylmethane diisocyanate and from 30 to 55 percent by weight polymethylene polyphenylene polyisocyanate with an isocyanurate content of 20 to 33 percent by weight. Polyurethane isocyanurate foams prepared from the reaction of these isocyanates with active hydrogen compounds seiected from the group consisting of diethyiene glycol and ethylene oxide adducts of trimethylolpropane, trimethylolethane, and glycerine exhibit good K-factors, low friability and low smoke density.

  一种稳定的异氰酸酯改性多异氰酸酯，其制备方法是将有机多异氰酸酯混合物进行三聚反应，该混合物中二苯基甲烷二异氰酸酯的重量百分比为 45%至 70%，其异构体混合物的重量百分比为 40%至 100%，4,4'-、0-50%（重量百分比）的 2,4-二苯基甲烷二异氰酸酯和 0-10%（重量百分比）的 2,2'-二苯基甲烷二异氰酸酯，以及 30-55%（重量百分比）的聚亚甲基多亚苯基多异氰酸酯，其异氰酸酯含量为 20-33%（重量百分比）。 由这些异氰酸酯与从二乙二醇和三羟甲基丙烷的环氧乙烷加成物、三羟甲基乙烷和甘油组成的组中提取的活性氢化合物反应制备的聚氨酯异氰尿酸酯泡沫具有良好的 K 系数、低易碎性和低烟密度。