5-<3-(bis-4-methoxyphenyl)-hydroxymethyl>-phenoxy-levulinic acid methyl ester | 169140-97-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5-<3-(bis-4-methoxyphenyl)-hydroxymethyl>-phenoxy-levulinic acid methyl ester
• CAS: 169140-97-0
• 化学式: C₂₇H₂₈O₇
• 分子量: 464.515
• InChiKey: SMWAJVNERIABGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.89
• 重原子数：
  34.0
• 可旋转键数：
  11.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  91.29
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  5-<3-(bis-4-methoxyphenyl)-hydroxymethyl>-phenoxy-levulinic acid methyl ester 在 甲醇 、 水 、 potassium carbonate 作用下， 反应 72.0h， 以96%的产率得到5-<3-(bis-4-methoxyphenyl)-hydroxymethyl>-phenoxy-levulinic acid
  参考文献：
  名称：

  A new colorimetric protecting group allowing deprotection under neutral conditions

  摘要：

  A 4,4'-dimethoxytrityl derivative of the levulinyl group has been developed for protection of nucleophilic functionalities such as hydroxyl groups by reaction of its symmetrical anhydride. It can rapidly be removed under mild conditions using a hydrazine-pyridinium acetate based buffer at near neutral pH. This protecting group can be detected with high sensitivity at 513 nm (epsilon = 78,600).

  DOI：

  10.1016/0040-4020(95)00228-z
• 作为产物：
  描述：

  1,2,4-三乙氧基苯 、 3-hydroxy-4'4''-dimethoxytritylcarbinol 在 sodium ethanolate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以29%的产率得到5-<3-(bis-4-methoxyphenyl)-hydroxymethyl>-phenoxy-levulinic acid methyl ester
  参考文献：
  名称：

  A new colorimetric protecting group allowing deprotection under neutral conditions

  摘要：

  A 4,4'-dimethoxytrityl derivative of the levulinyl group has been developed for protection of nucleophilic functionalities such as hydroxyl groups by reaction of its symmetrical anhydride. It can rapidly be removed under mild conditions using a hydrazine-pyridinium acetate based buffer at near neutral pH. This protecting group can be detected with high sensitivity at 513 nm (epsilon = 78,600).

  DOI：

  10.1016/0040-4020(95)00228-z

文献信息

• A new colorimetric protecting group allowing deprotection under neutral conditions
  作者：Eckart Leikauf、Hubert Köster

  DOI：10.1016/0040-4020(95)00228-z

  日期：1995.5

  A 4,4'-dimethoxytrityl derivative of the levulinyl group has been developed for protection of nucleophilic functionalities such as hydroxyl groups by reaction of its symmetrical anhydride. It can rapidly be removed under mild conditions using a hydrazine-pyridinium acetate based buffer at near neutral pH. This protecting group can be detected with high sensitivity at 513 nm (epsilon = 78,600).