8-oxo-rGTP | 21238-36-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: 8-oxo-rGTP
• 英文别名: 8-oxo-GTP；8-Hydroxyguanosine triphosphate；[[(2R,3S,4R,5R)-5-(2-amino-6,8-dioxo-1,7-dihydropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• CAS: 21238-36-8
• 化学式: C₁₀H₁₆N₅O₁₅P₃
• 分子量: 539.183
• InChiKey: JCHLKIQZUXYLPW-UMMCILCDSA-N

物化性质

• 密度：
  2.88±0.1 g/cm3(Predicted)
• 溶解度：
  甲醇（微溶）、水（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  -7.4
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  309
• 氢给体数：
  9
• 氢受体数：
  16

反应信息

• 作为产物：
  描述：

  Guanosine 5'-triphosphate 在 水 作用下， 以 aq. buffer 为溶剂， 生成 8-oxo-rGTP
  参考文献：
  名称：

  新型离子液体修饰的碳糊电极对鸟苷-5'-三磷酸的电化学氧化检测

  摘要：

  离子液体（IL）1-（3-氯-2-羟基-丙基）-3-甲基咪唑三氟乙酸盐用作制备改性碳糊电极（CPE）的改性剂。IL-CPE在pH 5.0的Britton-Robinson缓冲溶液中对鸟苷5'-三磷酸（5'-GTP）的氧化表现出出色的电催化活性。由于电极表面上存在较高的导电IL，因此大大促进了5'-GTP的电氧化，并出现了一个明确定义的不可逆氧化峰。电极反应是一个吸附控制的过程，计算了IL-CPE上5′-GTP的电化学参数，电子传递系数（α）为0.44，电子传递数（n）为1.99，表观异质电子传递速率常数（ķ小号），为2.21×10 -9小号-1和表面覆盖率（Γ Ť）为1.53×10 -10摩尔厘米-2。在选定的条件下，获得的氧化峰电流与5'-GTP浓度之间的线性校准曲线在2.0至1000.0μmolL -1的范围内，通过微分脉冲伏安法的检出限为0.049μmolL -1（3σ）。所提出的方

  DOI：

  10.1002/jccs.201300080

文献信息

• Methods for the electrochemical detection of target compounds
  申请人：Thorp Holden H.

  公开号：US20050123937A1

  公开（公告）日：2005-06-09

  The present invention concerns methods for the detection of a target nucleic acid sequence in a sample.

  本发明涉及检测样品中目标核酸序列的方法。
• Modified Diguanylate Cyclase-Phosphodiesterase and Method for Enzymatic Production of Cyclic-diGMP
  申请人：NESBITT Natasha M.

  公开号：US20140170689A1

  公开（公告）日：2014-06-19

  The present invention provides a recombinant polypeptide comprising a first portion and a second portion, wherein the sequence of the first portion is fully identical to amino acids 1 to 248 of the sequence set forth as SEQ ID NO:1 and the sequence of the second portion is other than amino acids 249 to 511 of the sequence set forth as SEQ ID NO:1.
• [EN] METHODS FOR THE ELECTROCHEMICAL DETECTION OF TARGET COMPOUNDS<br/>[FR] PROCEDES DE DETECTION ELECTROCHIMIQUE DE COMPOSES CIBLES
  申请人：UNIV NORTH CAROLINA

  公开号：WO2004092708A2

  公开（公告）日：2004-10-28

  The present invention concerns methods for the detection of a target nucleic acid sequence in a sample.
• [EN] COMPOSITION FOR ANTI-INFLAMMATION<br/>[FR] COMPOSITION ANTI-INFLAMMATOIRE
  申请人：SEOUL NAT UNIV IND FOUNDATION

  公开号：WO2007061237A1

  公开（公告）日：2007-05-31

  [EN] The present invention provides a composition for anti-inflammation comprising one or more ingredients of 8 -hydroxy guano sine (oh8G) and 8-hydroxydeoxyguanosine (oh8dG) as active ingredients. The present composition comprising one or more ingredients of oh8G and oh8dG suppresses the activity of Rac 2 of macrophage, thereby suppressing the activity of NADPH oxidase and also ROS production. Furthermore, the composition of the present invention suppresses the rising of blood concentration of pro-inflammatory cytokine induced by LPS, the increasing of MPO activity and Rac 2 activity, and the mortality of mouse due to LPS. Thus, the composition for anti-inflammation of the present invention can be used for treating various inflammatory diseases such as rheumatic arthritis, Lupus ethrythematosus, multiple scleroderma, adult respiratory distress syndrome (ARDS), etc., as an anti-inflammatory agent.
  [FR] La présente invention concerne une composition anti-inflammatoire comprenant un ou plusieurs ingrédients de 8-hydroxyguanosine (oh8G) et de 8-hydroxydeoxyguanosine (oh8dG) comme ingrédients actifs. Cette composition comprenant un ou plusieurs ingrédients de oh8G et de oh8dG supprime l'activité de Rac 2 de macrophage, ce qui supprime l'activité de la NADPH oxydase ainsi que la production de ROS. La composition de cette invention supprime également l'augmentation de la concentration dans le sang de cytokine pro-inflammatoire induite par LPS, l'augmentation de l'activité de MPO et de l'activité de Rac 2 et la mortalité des souris en raison du LPS. La composition anti-inflammatoire de cette invention peut ainsi être utilisée comme agent anti-inflammatoire pour traiter diverses maladies inflammatoires telles que l'arthrite rhumatismale, le lupus érythémateux, la sclérodermie en plaques, le syndrome de détresse respiratoire aiguë de l'adulte (SDRA), etc.
• [EN] METHODS OF PRODUCING CYCLIC DINUCLEOTIDES<br/>[FR] PROCÉDÉS DE PRODUCTION DE DINUCLÉOTIDES CYCLIQUES
  申请人：UNIV CALIFORNIA

  公开号：WO2018119117A1

  公开（公告）日：2018-06-28

  The present disclosure provides cyclic dinucleotides (CDNs), and methods of preparing and using the same. The subject methods can include contacting a CDN producing-enzyme with a precursor of a CDN under conditions sufficient to convert the precursor into a CDN. In some embodiments, the CDN producing-enzyme is a Hypr GGDEF enzyme. The methods can be performed in vitro or in a genetically modified host cell. Also provided are CDN compositions that find use in a variety of applications. Methods of modulating an immune response in an individual and methods of inhibiting a bacterial biofilm in an industrial system are also provided.