1,4-bis-(5-amino-pentyl)-piperazine | 69860-66-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,4-bis-(5-amino-pentyl)-piperazine
• 英文别名: 1,4-Bis-(5-amino-pentyl)-piperazin；5-[4-(5-amino-pentyl)-piperazin-1-yl]-pentylamine；5-[4-(5-Amino pentyl)-piperazin-1-yl]-pentylamine；5-[4-(5-aminopentyl)piperazin-1-yl]pentan-1-amine
• CAS: 69860-66-8
• 化学式: C₁₄H₃₂N₄
• 分子量: 256.435
• InChiKey: UZRGVQPIYMTXBJ-UHFFFAOYSA-N

物化性质

• 熔点：
  36-37 °C
• 沸点：
  210-212 °C(Press: 11 Torr)
• 密度：
  0.949±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  18
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(5-氯戊基)苯甲酰胺 在 盐酸 作用下， 生成 1,4-bis-(5-amino-pentyl)-piperazine
  参考文献：
  名称：

  v. Braun; Goll; Zobel, Chemische Berichte, 1926, vol. 59, p. 943

  摘要：

  DOI：

文献信息

• Salts of triazinic compounds with phosphorus oxyacids, and use of said compounds in self-extinguishing polymeric compositions
  申请人：MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA

  公开号：EP0537837A1

  公开（公告）日：1993-04-21

  Salts of triazinic compounds with phosphorus oxyacids, having the general formula (I): obtained by salifying oligomeric derivatives of 2,4, 6-triamino-1,3,5-triazine with a phosphorus-containing acid. The compounds with general formula (I) find use in particular as flame-retardant additives.

  三嗪化合物与含磷氧酸盐的盐，其一般式为(I)：通过用含磷酸盐对2,4,6-三氨基-1,3,5-三嗪的寡聚衍生物进行盐化而获得。具有一般式(I)的化合物特别用作阻燃添加剂。
• Organic Compounds
  申请人：Collingwood Stephen Paul

  公开号：US20080312217A1

  公开（公告）日：2008-12-18

  A Compound of formula (I) or tautomers, or stereoisomers, or solvates, or pharmaceutically acceptable salts thereof, wherein M 1 , M 1 , L 1 , L 2 , W 1 , W 2 , X 1 , X 2 , Y 1 , Y 2 , A, R 5 , and R 5a are as defined herein for the treatment of conditions mediated by the blockade of an epithelial sodium channel, particularly an inflammatory or allergic condition.

  化合物式（I）或其互变异构体、立体异构体、溶剂化物或药学上可接受的盐，其中M1、M1、L1、L2、W1、W2、X1、X2、Y1、Y2、A、R5和R5a的定义如本文所述，用于治疗由于阻断上皮钠通道介导的情况，特别是炎症或过敏症。
• Substituted pyrazines for use in the treatment of inflammatory or allergic conditions
  申请人：Novartis AG

  公开号：US07803804B2

  公开（公告）日：2010-09-28

  Disclosed herein are substituted pyrazine compounds and tautomers, stereoisomers, solvates, or pharmaceutically acceptable salts thereof for the treatment of conditions mediated by the blockade of an epithelial sodium channel, particularly an inflammatory or allergic condition, including compounds of formula I:

  本文介绍了用于治疗通过阻断上皮钠通道介导的炎症或过敏症状的替代吡嗪化合物及其互变异构体、立体异构体、溶剂化物或药学上可接受的盐，包括I式化合物。
• Self-extinguishing polymeric compositions
  申请人：MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA

  公开号：EP0415371A2

  公开（公告）日：1991-03-06

  Described are self-extinguishing polymeric compositions comprising: (a) from 89 to 45 parts by weight of thermoplastic polymer, or of polymer endowed with elastomeric properties; b) from 8 to 30 parts by weight of one or more ammonium and/or amine phosphate(s) and/or phosphonate(s); (c) from 3 to 25 parts by weight of one or more 2,4,6-triamino-1,3,5-triazine derivatives of general formula (I): wherein the groups R to R₄, Z, Z₁ and Z₂ and the subscripts a and b are as defined in claim 1.

  所述自熄灭聚合物组合物包括 (a) 89 至 45 份（按重量计）热塑性聚合物或具有弹性特性的聚合物； b) 8 至 30 份（按重量计）一种或多种磷酸铵和/或胺和/或膦酸盐； (c) 一种或多种通式(I)的 2,4,6-三氨基-1,3,5-三嗪衍生物，按重量计，3 至 25 份： 其中基团 R 至 R₄、Z、Z₁ 和 Z₂ 以及下标 a 和 b 如权利要求 1 所定义。
• Diamino-s-triazinon derivatives and self-extinguishing polymeric compositions containing them
  申请人：MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA

  公开号：EP0475367A1

  公开（公告）日：1992-03-18

  Disclosed are ameline derivatives of general formula (I): as defined in claim 1 and the use thereof as flame-proofing agents in self-extinguishing polymeric compositions.

  所公开的是通式（I）的酰胺啉衍生物： 及其在自熄性聚合物组合物中作为阻燃剂的用途。