N-(1-piperidinobenzyl)acetamide | 37733-79-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(1-piperidinobenzyl)acetamide
• 英文别名: N-[1-piperidinobenzyl]acetamide；piperidinobenzyl acetamide；PBA；N-(phenyl-piperidin-1-yl-methyl)-acetamide；N-(α-Piperidinobenzyl)-acetamid；N-(α-Piperidinobenzyl)acetamid；Acetamide, N-(phenyl-1-piperidinylmethyl)-；N-[phenyl(piperidin-1-yl)methyl]acetamide
• CAS: 37733-79-2
• 化学式: C₁₄H₂₀N₂O
• 分子量: 232.326
• InChiKey: XBSXEPGGZPRHPA-UHFFFAOYSA-N

物化性质

• 熔点：
  167 °C
• 沸点：
  400.2±38.0 °C(Predicted)
• 密度：
  1.077±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(1-piperidinobenzyl)acetamide 、 nickel dichloride 以 氯仿 为溶剂， 生成 dichloronickel;N-[phenyl(piperidin-1-yl)methyl]acetamide;dihydrate
  参考文献：
  名称：

  Kasim, A. N. Mohamed; Venkappayya, D.; Prabhu, G. Venkatesa, Journal of the Indian Chemical Society, 1999, vol. 76, # 2, p. 67 - 69

  摘要：

  DOI：
• 作为产物：
  描述：

  哌啶 、 乙酰胺 、 苯甲醛 反应 168.0h， 以64%的产率得到N-(1-piperidinobenzyl)acetamide
  参考文献：
  名称：

  Kasim, A. N. Mohamed; Venkappayya, D.; Prabhu, G. Venkatesa, Journal of the Indian Chemical Society, 1999, vol. 76, # 2, p. 67 - 69

  摘要：

  DOI：

文献信息

• Kasim, A. N. Mohamed; Venkappayya, D.; Prabhu, G. Venkatesa, Journal of the Indian Chemical Society, 1999, vol. 76, # 2, p. 67 - 69
  作者：Kasim, A. N. Mohamed、Venkappayya, D.、Prabhu, G. Venkatesa

  DOI：——

  日期：——
• Peroxo complexes of uranium(VI) containing nitrogen and oxygen donor ligands
  作者：Balgar Singh、Simpy Mahajan、H. N. Sheikh、Mohita Sharma、Bansi Lal Kalsotra

  DOI：10.1134/s003602361208013x

  日期：2012.8

  The uranium(VI) peroxo complexes containing Mannich base ligands having composition [UO(O-2)L-L(NO3)(2)] where L-L = morpholinobenzyl acetamide (MBA), piperidinobenzyl acetamide (PBA), morpholinobenzyl benzamide (MBB), piperidinobenzyl benzamide (PBB), morpholinomethyl benzamide (MMB), piperidinomethyl benzamide (PMB), morpholinobenzyl formamide (MBF)}, piperidinobenzyl formamide (PBF) are reported. In a typical reaction UO2(NO3)(2) center dot 6H(2)O (1 mmol, 0.502 g) was dissolved in methanol. An equimolar (1 mmol) methanolic solution (30 mL) of the ligand (Mannich bases) was added to a solution of uranyl nitrate followed by addition of potassium hydroxide (KOH) (2 mmol, 0.1122 g). The solution was refluxed for 15 min and then 10 mL of 30% hydrogen peroxide (H2O2) was added dropwise and was refluxed for an additional 1 h. The synthesized complexes have been characterized by various physico-chemical techniques, viz. elemental analysis, molar conductivity, magnetic susceptibility measurements, infra red, electronic, mass spectral and TGA/DTA studies. These studies revealed that the synthesized complexes are non-electrolytic and diamagnetic in nature. The ligands are bound to metal in a bidentate mode through carbonyl oxygen and the ring nitrogen. Thermal analysis result provides conclusive evidence for the absence of water molecule in the complexes. Mass spectra confirm the molecular mass of the complexes. Antibacterial activity of complexes revealed enhanced activity of complexes as compared to corresponding free ligands. Molecular modeling suggests pentagonal bipyramidal structure for complexes.

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