1-(2-piperidyl)-butan-2-one | 91055-60-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(2-piperidyl)-butan-2-one
• 英文别名: 1-(piperidin-2-yl)butan-2-one；2-(Propionyl-methyl)piperidin；1-(Piperidyl-2)butanon-2；1-(2-Piperidyl)-2-pentanon；1-piperidin-2-ylbutan-2-one
• CAS: 91055-60-6
• 化学式: C₉H₁₇NO
• 分子量: 155.24
• InChiKey: RHLYAWVHQJCIJV-UHFFFAOYSA-N

物化性质

• 沸点：
  215.6±13.0 °C(Predicted)
• 密度：
  0.912±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,5-diaminopentane dihydrochloride 、 丙酰乙酸乙酯 在 α,ω-diamine transaminase YgjG from Escherichia coli K12 、 sodium pyruvate 作用下， 以 甲醇 为溶剂， 反应 18.0h， 以55%的产率得到1-(2-piperidyl)-butan-2-one
  参考文献：
  名称：

  通过一锅水解、氨基转移和脱羧曼尼希反应仿生合成 2-取代 N-杂环生物碱†

  摘要：

  基于哌啶和吡咯烷的杂环是天然产物和药物活性分子中的关键部分。报道了一种基于脂肪酶与 α,ω-二胺转氨酶组合的新型多酶方法，开辟了广泛的 2-取代 N-杂环生物碱的合成、分离和表征。

  DOI：

  10.1039/c8cc06759g

文献信息

• Pharmaceutically acceprable salts of aporphine compounds of carboxyl group-containing agents and methods for preparing the same
  申请人：Fan Chin-Tsai

  公开号：US20090318488A1

  公开（公告）日：2009-12-24

  The present invention discloses novel pharmaceutically acceptable salts of aporphine compounds and carboxyl-group containing agents. Also, the present invention discloses methods for preparing the pharmaceutically acceptable salts. These pharmaceutically acceptable salts are suitable for use in treating and/or preventing hyperglycemic disease and/or several oxidative stress related diseases.

  本发明揭示了阿波啶化合物和含羧基的试剂的新型药用可接受盐。此外，本发明还揭示了制备药用可接受盐的方法。这些药用可接受盐适用于治疗和/或预防高血糖病和/或几种与氧化应激相关的疾病。
• Alkaloids of some european and macaronesian sedoideae and sempervivoideae (Crassulaceae)
  作者：Jan F. Stevens、Henk 'T Hart、Henk Hendriks、Theo M. Malingré

  DOI：10.1016/s0031-9422(00)97554-x

  日期：1992.1

  Some 22 pyrrolidine and piperdine alkaloids were detected in the leafy parts of Sedum acre, S. aetnense, S. anglicum, S. brissemoreti, S. farinosum, S. fusiforme, S. lancerottense, S. melanantherum, and S. nudum. In addition to the alkaloids known from S. acre, 1-(2-pyrrolidyl)-propan-2-one and 2-monosubstituted piperidine alkaloids bearing butan-2-one, butan-2-ol, pentan-2-one and pentan-2-ol sidechains were identified. Phenylethylamine was isolated from the vegetative parts of S. album. In S. lydium, S. meyeri-johannis, and 16 species of S. series Rupestria, Aeonium, Greenovia, Jovibarba and Sempervivum no alkaloids could be detected. The results indicate a correlation between the presence of alkaloids and the major evolutionary trends in the European and Macaronesian Crassulaceae.
• Aporphine compounds and pharmaceutical use thereof
  申请人：Fan Chin-Tsai

  公开号：US20090318489A1

  公开（公告）日：2009-12-24

  The present invention discloses novel aporphine derivatives. Also, the present invention discloses that these novel aporphine derivatives can be used for treating oxidative stress induced diseases such as cardiovascular disease, diabetes, aging, Alzheimer's disease, kidney disease, cancer or brain ischemic disease etc.
• US8093260B2
  申请人：——

  公开号：US8093260B2

  公开（公告）日：2012-01-10
• US8202995B2
  申请人：——

  公开号：US8202995B2

  公开（公告）日：2012-06-19