Dibenzofurane-2,8-dicarboxylic acid dichloride | 5001-64-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: Dibenzofurane-2,8-dicarboxylic acid dichloride
• 英文别名: dibenzofuran-2,8-dicarbonyl dichloride；Dibenzofuran-2,8-dicarbonylchlorid；Dibenzofuran-2,8-dicarbonyl chloride
• CAS: 5001-64-9
• 化学式: C₁₄H₆Cl₂O₃
• 分子量: 293.106
• InChiKey: DTIVJKZZBXDXRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  47.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Dibenzofurane-2,8-dicarboxylic acid dichloride 以43%的产率得到
  参考文献：
  名称：

  ALBRECHT W. L.; FLEMING R. W.; HORGAN S. W.; MAYER G. D., J. MED. CHEM. , 1977, 20, NO 3, 364-371

  摘要：

  DOI：

文献信息

• Platelet Aggregation Inhibiting and Anticoagulant Effects of Oligoamines, XW: Oligoamines with Fluorescent Properties Part A: Fluorescent Bridged Nitrogen Functions
  作者：K. Rehse、T. Seidel

  DOI：10.1002/ardp.19923250408

  日期：——

  formation induced by thromboplastin by more than 75% in a 200 μmolar concentration. Both effect do not run parallel. The most space consuming fluorophores show the smallest inhibition of the platelet aggregation. Best results were obtained with an azulene, acenaphthene or naphthalene moiety between the two basic nitrogen functions.

  已经合成了 11 种二甲胺和一种具有荧光特性的二甲基亚胺。它们都在 14-75 μmol/L 的浓度范围内显示出抗血小板活性（IC50，Born-test）。其中五个在 200 微摩尔浓度下抑制了凝血活酶诱导的纤维蛋白形成超过 75%。两种效果不会并行运行。占用空间最多的荧光团对血小板聚集的抑制作用最小。在两个碱性氮官能团之间使用芘、苊或萘部分获得了最佳结果。
• Pharmaceutically useful nitrogen containing heterocyclic derivatives
  申请人：Richardson-Merrell Inc.

  公开号：US03937833A1

  公开（公告）日：1976-02-10

  Bis-basic substituted aromatic polycyclic compounds of the following structure are useful in treating conditions of delayed hypersensitivity: ##SPC1## Wherein [W] represents an aromatic polycyclic nucleus selected from fluoranthene, fluorene, fluoren-9-ol, fluoren-9-one, dibenzofuran, dibenzothiophene, carbazole, N-(lower)alkyl carbazole, xanthene, xanthone, thioxanthene, phenoxathiin, or anthraquinone; Y represents carbonyloxy, carbonylthio, oxygen, divalent sulfur or carbonyl with the provisos that when Y is carbonyloxy or carbonylthio, [W] is other than thioxanthene, phenoxathiin or anthraquinone, when Y is oxygen or divalent sulfur, [W] is other than thioxanthene or phenoxathiin, and when Y is carbonyl, [W] is other than fluoren-9-ol or anthraquinone; A represents a straight or branched alkylene chain of from 1 to 6 carbon atoms with the proviso that when Y is carbonyloxy or carbonylthio, A contains at least 2 straight chain carbon atoms, that is, an ethylene radical; R represents hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, phenyl or benzyl; and pharmaceutically useful acid addition salts.

  以下结构的Bis-基取代芳香族多环化合物在治疗延迟型超敏反应方面很有用：##SPC1## 其中[W]代表从荧蒽、芴、芴-9-醇、芴-9-酮、二苯并呋喃、二苯并噻吩、咔唑、N-(较低)烷基咔唑、苯酚氧噻吩或蒽醌中选的芳香族多环核；Y代表羰氧基、羰硫基、氧、二价硫或羰基，但当Y为羰氧基或羰硫基时，[W]不是噻吩、苯酚氧噻吩或蒽醌，当Y为氧或二价硫时，[W]不是噻吩或苯酚氧噻吩，当Y为羰基时，[W]不是芴-9-醇或蒽醌；A代表1至6个碳原子的直链或支链烷基链，但当Y为羰氧基或羰硫基时，A含有至少2个直链碳原子，即乙烯基；R代表氢、1至4个碳原子的直链或支链低级烷基、苯基或苄基；以及药用酸盐。
• Ruban,E.M.; Kornilov,M.Y., Journal of Organic Chemistry USSR (English Translation), 1973, vol. 9, p. 2601 - 1605
  作者：Ruban,E.M.、Kornilov,M.Y.

  DOI：——

  日期：——
• US3937833A
  申请人：——

  公开号：US3937833A

  公开（公告）日：1976-02-10
• US3953602A
  申请人：——

  公开号：US3953602A

  公开（公告）日：1976-04-27