(R)-3-Methyl-2-triisopropylsilanyloxy-butyraldehyde | 681488-43-7

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (R)-3-Methyl-2-triisopropylsilanyloxy-butyraldehyde
• 英文别名: (2R)-3-Methyl-2-{[tri(propan-2-yl)silyl]oxy}butanal；(2R)-3-methyl-2-tri(propan-2-yl)silyloxybutanal
• CAS: 681488-43-7
• 化学式: C₁₄H₃₀O₂Si
• 分子量: 258.476
• InChiKey: GHMUEERLTRPXOV-AWEZNQCLSA-N

物化性质

• 沸点：
  269.0±23.0 °C(Predicted)
• 密度：
  0.858±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (R)-3-Methyl-2-triisopropylsilanyloxy-butyraldehyde 在 LiHMDSA 作用下， 以 四氢呋喃 为溶剂， 反应 10.99h， 生成 2-[(2-hydroxyethylamino)methylene]-7-methyl-3-oxo-6-(triisopropylsilanyloxy)oct-4-enoic acid benzyl ester
  参考文献：
  名称：

  Multistep Microwave-Assisted Solvent-Free Organic Reactions: Synthesis of 4-Oxo-tetrahydro-pyridine

  摘要：

  Preparation and ring-closure of 2-dimethylaminomethylene-5-substituted-3-oxo-pent-4-enoic acid benzyl esters to dihydropyridine rings are efficiently and quickly carried out under solvent-free conditions in an open-vessel microwave system. The syntheses of 1,6-disubstituted-4-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid benzyl esters are reported.

  DOI：

  10.1081/scc-120027272

文献信息

• Multistep Microwave-Assisted Solvent-Free Organic Reactions: Synthesis of 4-Oxo-tetrahydro-pyridine
  作者：Mauro Panunzio、Maria Antonietta Lentini、Eileen Campana、Giorgio Martelli、Emiliano Tamanini、Paola Vicennati

  DOI：10.1081/scc-120027272

  日期：2004.1

  Preparation and ring-closure of 2-dimethylaminomethylene-5-substituted-3-oxo-pent-4-enoic acid benzyl esters to dihydropyridine rings are efficiently and quickly carried out under solvent-free conditions in an open-vessel microwave system. The syntheses of 1,6-disubstituted-4-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid benzyl esters are reported.