S-methyl-5'-thio-2'-deoxy-adenosine | 5605-64-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 2 '，5'-二脱氧核苷
• 英文名称: S-methyl-5'-thio-2'-deoxy-adenosine
• 英文别名: Methyl-<2'-desoxy-adenosyl-(5')>-sulfid；5'-S-Methylthio-5'-desoxyadenosin；(2S,3S,5R)-5-(6-aminopurin-9-yl)-2-(methylsulfanylmethyl)oxolan-3-ol
• CAS: 5605-64-1
• 化学式: C₁₁H₁₅N₅O₂S
• 分子量: 281.338
• InChiKey: HYLJGASTSTUVMR-XLPZGREQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  124
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  S-methyl-5'-thio-2'-deoxy-adenosine 在 potassium phosphate buffer 、 rh 5'-deoxy-5'-methylthioadenosine phosphorylase 作用下， 生成 、 腺嘌呤
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of novel human 5′-deoxy-5′-methylthioadenosine phosphorylase (MTAP) substrates

  摘要：

  The structure-based design, chemical synthesis, and biological evaluation of novel MTAP substrates are described. These compounds incorporate various C5'-moieties and are shown to have different k(cat)/K values compared with the natural MTAP substrate (MTA). (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.03.107

文献信息

• METHOD FOR THE SELECTIVE THERAPY OF DISEASE
  申请人：Lubin, Adam

  公开号：EP2192905A2

  公开（公告）日：2010-06-09
• THERAPY OF TUMORS AND INFECTIOUS AGENTS DEFICIENT IN METHYLTHIOADENOSINE PHOSPHORYLASE
  申请人：Lubin Adam

  公开号：US20150119351A1

  公开（公告）日：2015-04-30

  Methods for treating diseases in humans and vertebrate animals are provided using competitive antagonists of cellular metabolites combined with a protective agent for protecting host cells from toxic effects of the drugs. Also provided are kits comprising competitive antagonists and suitable protective agents. In addition, screening methods for identifying competitive antagonists, protective agents and potentiating agents, for use according to the methods of the invention, are provided.
• US8796241B2
  申请人：——

  公开号：US8796241B2

  公开（公告）日：2014-08-05
• [EN] METHOD FOR THE SELECTIVE THERAPY OF DISEASE<br/>[FR] PROCÉDÉ POUR LA THÉRAPIE SÉLECTIVE D'UNE MALADIE
  申请人：LUBIN ADAM

  公开号：WO2009032057A2

  公开（公告）日：2009-03-12

  Methods for treating diseases in humans and vertebrate animals are provided using competitive antagonists of cellular metabolites combined with a protective agent for protecting host cells from toxic effects of the drugs. Also provided are kits comprising competitive antagonists and suitable protective agents. In addition, screening methods for identifying competitive antagonists, protective agents and potentiating agents, for use according to the methods of the invention, are provided.
• Design, synthesis, and biological evaluation of novel human 5′-deoxy-5′-methylthioadenosine phosphorylase (MTAP) substrates
  作者：Pei-Pei Kung、Luke R. Zehnder、Jerry J. Meng、Stanley W. Kupchinsky、Donald J. Skalitzky、M. Catherine Johnson、Karen A. Maegley、Anne Ekker、Leslie A. Kuhn、Peter W. Rose、Laura A. Bloom

  DOI：10.1016/j.bmcl.2005.03.107

  日期：2005.6

  The structure-based design, chemical synthesis, and biological evaluation of novel MTAP substrates are described. These compounds incorporate various C5'-moieties and are shown to have different k(cat)/K values compared with the natural MTAP substrate (MTA). (c) 2005 Elsevier Ltd. All rights reserved.