3,3'-(1,4-哌嗪二基)二(2-羟基-1-丙烷磺酸)二水合物 | 918131-36-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 3,3'-(1,4-哌嗪二基)二(2-羟基-1-丙烷磺酸)二水合物
• 英文名称: 3,3'-(Piperazine-1,4-diyl)bis(2-hydroxypropane-1-sulfonic acid) dihydrate
• 英文别名: 2-hydroxy-3-[4-(2-hydroxy-3-sulfopropyl)piperazin-1-yl]propane-1-sulfonic acid;dihydrate
• CAS: 918131-36-9
• 化学式: C10H26N2O10S2
• 分子量: 398.5
• InChiKey: PDSOJBZKKTTWHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.55
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  174
• 氢给体数：
  6
• 氢受体数：
  12

安全信息

• 海关编码：
  2933599090

文献信息

• Methods and compositions for the detection of biological molecules using a two particle complex
  申请人：Bard J. Allen

  公开号：US20060078912A1

  公开（公告）日：2006-04-13

  The invention provides methods of detecting analytes of interest in a sample using electrogenerated chemiluminescence. The invention also provides compositions comprising at least one solid support that entraps or contains an electrogenerated chemiluminescent moiety.

  本发明提供了使用电化学发光检测样品中感兴趣的分析物的方法。本发明还提供了包含至少一种固体支持物的组合物，该固体支持物包含或限制电化学发光基团。
• Integral multilayer analytical element for analysis of ammonia-forming substrate
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0204334A2

  公开（公告）日：1986-12-10

  An integral multilayer analytical element for the analysis of an ammonia-forming substrate comprising: (I) a light-transmissive, liquid-impermeable support; (II) an ammonia indicator layer containing a reagent capable of undergoing a detectable change by gaseous ammonia; (III) a liquid barrier layer which allows gaseous ammonia passing therethrough; (IV) an ammonia-forming substrate reaction layer containing a reagent capable of reacting with an ammonia-forming substrate to form gaseous ammonia; (V) an intrinsic ammonia trapping layer containing a reagent which acts on intrinsic ammonia to convert it into a form which can not reach said reaction layer; and (VI) a porous spreading layer, in a laminate form.

  用于分析氨形成基质的整体多层分析元件，包括 (I) 透光、不透液体的支撑层； (II) 氨指示剂层，内含能被气态氨产生可检测变化的试剂； (III) 允许气态氨通过的液体阻隔层； (IV) 氨形成基质反应层，含有能与氨形成基质反应形成气态氨的试剂； (V) 本征氨捕集层，含有一种试剂，该试剂对本征氨起作用，将其转化为一种无法到达所述反应层的形式；以及 (VI) 多孔扩散层、 层状。
• Integral multilayer analytical element for determination of ammonia or ammonia-producing substance
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0481436A1

  公开（公告）日：1992-04-22

  An integral multilayer analytical element for the determination of ammonia or an ammonia-producing substance comprising a light-transmissive liquid-impermeable support, an indicator layer containing an indicator which produces a detectable change by gaseous ammonia, a liquid permeation barrier layer, a reagent layer containing an alkaline buffer and optionally a reagent capable of reacting with a substance to produce ammonia and a spreading layer laminated in this order, which is improved by that the indicator layer contains a polyvinyl alkyl ether, and/or which is improved by that the surface of said support facing toward the indicator layer is undercoated with a polyvinyl alkyl ether, a hydroxyalkyl cellulose, an alkyl cellulose, polystyrene, a polyalkyl methacrylate, polyvinylidene chloride, polyvinyl alcohol or polyvinyl pyrrolidone, substantially not containing ammonia and ammonium ion. By using the above analytical element, ammonia or an ammonia-producing substance can be analyzed at a high coloring optical density and a high accuracy. The measuring accuracy is further improved by lowering the background optical density.

  一种用于测定氨或产生氨的物质的整体多层分析元件，包括透光的液体不透性支撑层、含有能通过气态氨产生可检测变化的指示剂的指示剂层、液体渗透阻隔层、含有碱性缓冲液和可选择的能与物质反应产生氨的试剂的试剂层以及按此顺序层叠的铺展层、其改进之处在于指示剂层含有聚乙烯烷基醚，和/或其改进之处在于所述支撑物朝向指示剂层的表面下涂有聚乙烯烷基醚、羟烷基纤维素、烷基纤维素、聚苯乙烯、聚烷基甲基丙烯酸酯、聚偏二氯乙烯、聚乙烯醇或聚乙烯吡咯烷酮，基本上不含氨和铵离子。通过使用上述分析元件，可以在高着色光密度和高精度下分析氨或产氨物质。通过降低本底光密度，可进一步提高测量精度。
• RAGE fusion proteins, formulations, and methods of use thereof
  申请人：TransTech Pharma Inc.

  公开号：EP2380983A2

  公开（公告）日：2011-10-26

  Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to the N-terminus of an immunoglobulin CH2 domain. Also disclosed are RAGE fusion protein formulations and the use of the RAGE fusion proteins and RAGE fusion protein formulations as therapeutics for RAGE-mediated pathologies.

  公开的 RAGE 融合蛋白包括与第二种非 RAGE 多肽连接的 RAGE 多肽序列。RAGE 融合蛋白可利用 RAGE 多肽结构域，该结构域包括一个 RAGE 配体结合位点和一个直接连接到免疫球蛋白 CH2 结构域 N 端的结构域间连接器。还公开了 RAGE 融合蛋白制剂以及 RAGE 融合蛋白和 RAGE 融合蛋白制剂作为治疗 RAGE 介导的病症的用途。
• Alpha 5 - beta 1 antibodies and their uses
  申请人：Bristol-Myers Squibb Company

  公开号：EP2650017A2

  公开（公告）日：2013-10-16

  The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-α5β1 antibodies or antigen binding portions thereof described herein.

  本公开提供了分离的单克隆抗体，特别是人类单克隆抗体，或其抗原结合部分，它们能以高亲和力与整合素α5β1特异性结合。此外，还提供了编码所公开抗体的核酸分子、表达载体、宿主细胞以及表达所公开抗体的方法。还提供了包含抗体或其抗原结合部分的免疫结合剂、双特异性分子和药物组合物。本公开还提供了使用本文所述抗α5β1抗体或其抗原结合部分治疗各种癌症的方法。