N,N'-Di-tert-butyl-N-methylharnstoff | 39551-21-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: N,N'-Di-tert-butyl-N-methylharnstoff
• 英文别名: N-Methyl-N,N'-di--harnstoff；N-Methyl-N,N'-di-(tert.-butyl)-harnstoff；1,3-Ditert-butyl-1-methylurea
• CAS: 39551-21-8
• 化学式: C₁₀H₂₂N₂O
• 分子量: 186.297
• InChiKey: VIJHXQJCHAIHSP-UHFFFAOYSA-N

物化性质

• 沸点：
  296.8±9.0 °C(Predicted)
• 密度：
  0.900±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N,N′-二叔丁基碳二亚胺 在 sodium hydroxide 作用下， 生成 N,N'-Di-tert-butyl-N-methylharnstoff
  参考文献：
  名称：

  Hartke,K. et al., Justus Liebigs Annalen der Chemie, 1972, vol. 762, p. 167 - 177

  摘要：

  DOI：

文献信息

• Substituted Fused Pyrimidine Compounds
  申请人：Palle Venkata

  公开号：US20120115864A1

  公开（公告）日：2012-05-10

  The present invention discloses substituted fused pyrimidine compounds of formula (I), their tautomers, polymorphs, stereoisomers, solvates, pharmaceutically acceptable salts, or pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by adenosine receptor (AR) activity. The compounds of the present invention are useful in the treatment, prevention or suppression of diseases and disorders that may be susceptible to improvement by antagonism of the adenosine receptor, such as asthma, chronic obstructive pulmonary disorder, angiogenesis, pulmonary fibrosis, emphysema, allergic diseases, inflammation, reperfusion injury, myocardial ischemia, atherosclerosis, hypertension, congestive heart failure, retinopathy, diabetes mellitus, obesity, inflammatory gastrointestinal tract disorders, and/or autoimmune diseases.

  本发明公开了式(I)的取代融合嘧啶化合物，它们的互变异构体、多晶形态、立体异构体、溶剂合物、药学上可接受的盐或含有它们的药物组合物，以及治疗由腺苷受体(AR)活性介导的疾病和病况的方法。本发明的化合物在治疗、预防或抑制可能通过腺苷受体拮抗而得到改善的疾病和疾病中具有用处，如哮喘、慢性阻塞性肺疾病、血管生成、肺纤维化、肺气肿、过敏性疾病、炎症、再灌注损伤、心肌缺血、动脉粥样硬化、高血压、充血性心力衰竭、视网膜病变、糖尿病、肥胖、炎症性胃肠道疾病和/或自身免疫性疾病。
• Lambrecht, Johanna; Zsolnai, Laszlo; Huttner, Gottfried, Chemische Berichte, 1981, vol. 114, # 11, p. 3655 - 3666
  作者：Lambrecht, Johanna、Zsolnai, Laszlo、Huttner, Gottfried、Jochims, Johannes C.

  DOI：——

  日期：——
• SPATIALLY-DEFINED MACROCYCLES INCORPORATING PEPTIDE BOND SURROGATES
  申请人：Deslongchamps Pierre

  公开号：US20090312540A1

  公开（公告）日：2009-12-17

  Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target, in particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
• US7550431B2
  申请人：——

  公开号：US7550431B2

  公开（公告）日：2009-06-23
• US8557765B2
  申请人：——

  公开号：US8557765B2

  公开（公告）日：2013-10-15