tert-butyl (2-(5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1H-indol-1-yl)ethyl)carbamate | 1304787-86-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tert-butyl (2-(5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1H-indol-1-yl)ethyl)carbamate
• 英文别名: tert-Butyl (2-(5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1H-indol-1-yl)ethyl)carbamate；tert-butyl N-[2-[5-[4-(4-chlorophenoxy)piperidine-1-carbonyl]indol-1-yl]ethyl]carbamate
• CAS: 1304787-86-7
• 化学式: C₂₇H₃₂ClN₃O₄
• 分子量: 498.022
• InChiKey: TVVPPJNFZJHNPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl (2-(5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1H-indol-1-yl)ethyl)carbamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以51%的产率得到(1-(2-aminoethyl)-1H-indol-5-yl)(4-(4-chlorophenoxy)piperidin-1-yl)methanone
  参考文献：
  名称：

  [EN] ARYL CARBOXAMIDE DERIVATIVES AS TTX-S BLOCKERS
  [FR] DÉRIVÉS D'ARYLCARBOXAMIDE COMME BLOQUEURS DE TTX-S

  摘要：

  本发明涉及式（I）的芳基羧酰胺衍生物，其中Ar1为苯基；Ar2为芳基；n为1-4；X为-O-、-S-、-SO-或-SO2-，其前体药物或其药学上可接受的盐，具有作为TTX-S通道的电压门控钠通道的阻塞活性，并且在治疗或预防涉及电压门控钠通道的疾病和疾病中如疼痛等方面具有用途。该发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及电压门控钠通道的疾病如疼痛中的用途。

  公开号：

  WO2011058766A1
• 作为产物：
  描述：

  4-(4-氯苯氧基)哌啶 在 sodium hydride 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 5.0h， 生成 tert-butyl (2-(5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1H-indol-1-yl)ethyl)carbamate
  参考文献：
  名称：

  [EN] ARYL CARBOXAMIDE DERIVATIVES AS TTX-S BLOCKERS
  [FR] DÉRIVÉS D'ARYLCARBOXAMIDE COMME BLOQUEURS DE TTX-S

  摘要：

  本发明涉及式（I）的芳基羧酰胺衍生物，其中Ar1为苯基；Ar2为芳基；n为1-4；X为-O-、-S-、-SO-或-SO2-，其前体药物或其药学上可接受的盐，具有作为TTX-S通道的电压门控钠通道的阻塞活性，并且在治疗或预防涉及电压门控钠通道的疾病和疾病中如疼痛等方面具有用途。该发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及电压门控钠通道的疾病如疼痛中的用途。

  公开号：

  WO2011058766A1

文献信息

• ARYL CARBOXAMIDE DERIVATIVES AS TTX-S BLOCKERS
  申请人：Yamagishi Tatsuya

  公开号：US20120232052A1

  公开（公告）日：2012-09-13

  The present invention relates to aryl carboxamide derivatives of formula (I), wherein Ar 1 is phenyl; Ar 2 is aryl; n is 1-4; X is —O—, —S—, —SO— or —SO 2 —, a prodrug thereof or a pharmaceutically acceptable salt thereof, which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of such disorders and diseases as pain in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases as pain in which voltage gated sodium channels are involved.

  本发明涉及公式（I）的芳基羧酰胺衍生物，其中Ar1是苯基；Ar2是芳基；n为1-4；X为—O—、—S—、—SO—或—SO2—，其前体药物或其药学上可接受的盐，具有阻断电压门控钠通道如TTX-S通道的活性，并在治疗或预防涉及电压门控钠通道的疾病和疾病，如疼痛方面中有用。本发明还涉及包含这些化合物的制药组合物以及这些化合物和组合物在预防或治疗涉及电压门控钠通道的疾病和疾病，如疼痛方面的使用。
• Aryl carboxamide derivatives as TTX-S blockers
  申请人：Yamagishi Tatsuya

  公开号：US09051296B2

  公开（公告）日：2015-06-09

  The present invention relates to aryl carboxamide derivatives of formula (I), wherein Ar1 is phenyl; Ar2 is aryl; n is 1-4; X is —O—, —S—, —SO— or —SO2—, a prodrug thereof or a pharmaceutically acceptable salt thereof, which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of such disorders and diseases as pain in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases as pain in which voltage gated sodium channels are involved.

  本发明涉及式(I)的芳基羧酰胺衍生物，其中Ar1为苯基；Ar2为芳基；n为1-4；X为—O—，—S—，—SO—或—SO2—，其前药或其药学上可接受的盐具有钠离子通道阻滞活性，特别是TTX-S通道，可用于治疗或预防涉及钠离子通道的疾病和疾病，如疼痛。本发明还涉及包含这些化合物的制药组合物以及这些化合物和组合物在预防或治疗涉及钠离子通道的疾病和疾病，如疼痛中的用途。
• [EN] ARYL CARBOXAMIDE DERIVATIVES AS TTX-S BLOCKERS<br/>[FR] DÉRIVÉS D'ARYLCARBOXAMIDE COMME BLOQUEURS DE TTX-S
  申请人：RAQUALIA PHARMA INC

  公开号：WO2011058766A1

  公开（公告）日：2011-05-19

  The present invention relates to aryl carboxamide derivatives of formula (I), wherein Ar1 is phenyl; Ar2 is aryl; n is 1-4; X is -O-, -S-, -SO- or -SO2-, a prodrug thereof or a pharmaceutically acceptable salt thereof, which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of such disorders and diseases as pain in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases as pain in which voltage gated sodium channels are involved.

  本发明涉及式（I）的芳基羧酰胺衍生物，其中Ar1为苯基；Ar2为芳基；n为1-4；X为-O-、-S-、-SO-或-SO2-，其前体药物或其药学上可接受的盐，具有作为TTX-S通道的电压门控钠通道的阻塞活性，并且在治疗或预防涉及电压门控钠通道的疾病和疾病中如疼痛等方面具有用途。该发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及电压门控钠通道的疾病如疼痛中的用途。