N-(cyanoethyl)-N-methyl-5'-amino-5'-deoxyadenosine | 72648-38-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• 英文名称: N-(cyanoethyl)-N-methyl-5'-amino-5'-deoxyadenosine
• 英文别名: 5'-<(2-cyanoethyl)methylamino>-5'-deoxyadenosine；5'-[(2-cyanoethyl)methylamino]-5'-deoxyadenosine；3-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-methylamino]propanenitrile
• CAS: 72648-38-5
• 化学式: C₁₄H₁₉N₇O₃
• 分子量: 333.35
• InChiKey: IREPBAGBNVSCLA-IDTAVKCVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  146
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  N-(cyanoethyl)-N-methyl-5'-amino-5'-deoxyadenosine 在 硼烷 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 5'-<(3-aminopropyl)methylamino>-5'-deoxyadenosine
  参考文献：
  名称：

  多胺生物合成抑制剂。8.底物类似物对哺乳动物S-腺苷-L-甲硫氨酸脱羧酶的不可逆抑制。

  摘要：

  DOI：

  10.1021/jm00176a004
• 作为产物：
  描述：

  3-甲胺基丙腈 、 5'-对甲苯磺酸腺苷 反应 168.0h， 以42%的产率得到N-(cyanoethyl)-N-methyl-5'-amino-5'-deoxyadenosine
  参考文献：
  名称：

  S-腺苷-L-蛋氨酸脱羧酶催化反应的化学稳定产物类似物的合成和生化性质。

  摘要：

  脱羧化S-腺苷-L-蛋氨酸（dc-SAM）的结构类似物，它是由S-腺苷-L-蛋氨酸脱羧酶（SAM-DC）催化的反应产物，在分子的侧链部分有修饰合成，并研究了其抑制SAM-DC的能力。主要研究了用氮原子代替硫的化合物。这些抑制研究的数据导致了对结合到SAM-DC上所需的结构特征的描绘。结论是，末端伯氨基，末端羧基和the官能度对于在SAM-DC上结合不是必需的。还发现dc-SAM的类似物仍能与该酶形成偶氮甲碱，其中用氮代替硫是唯一的修饰。

  DOI：

  10.1021/jm00347a014

文献信息

• Synthesis and biochemical properties of chemically stable product analogs of the reaction catalyzed by S-adenosyl-L-methionine decarboxylase
  作者：Michael Kolb、Charles Danzin、Jacqueline Barth、Nicole Claverie

  DOI：10.1021/jm00347a014

  日期：1982.5

  Structural analogues of decarboxylated S-adenosyl-L-methionine (dc-SAM), product of the reaction catalyzed by S-adenosyl-L-methionine decarboxylase (SAM-DC), with modifications in the side-chain portion of the molecule have been synthesized, and their ability to inhibit SAM-DC has been investigated. Mainly, compounds with a nitrogen atom in place of the sulfur were investigated. The data from these

  脱羧化S-腺苷-L-蛋氨酸（dc-SAM）的结构类似物，它是由S-腺苷-L-蛋氨酸脱羧酶（SAM-DC）催化的反应产物，在分子的侧链部分有修饰合成，并研究了其抑制SAM-DC的能力。主要研究了用氮原子代替硫的化合物。这些抑制研究的数据导致了对结合到SAM-DC上所需的结构特征的描绘。结论是，末端伯氨基，末端羧基和the官能度对于在SAM-DC上结合不是必需的。还发现dc-SAM的类似物仍能与该酶形成偶氮甲碱，其中用氮代替硫是唯一的修饰。
• 5′,-substituted adenosynes preparation thereof and use as inhibitors of S-adenosylmethionine decarboxylase
  申请人：Secrist, III John A.

  公开号：US08637485B2

  公开（公告）日：2014-01-28

  The crystal structure of the complex of S-adenosylmethionine methyl ester with hΛdoMetDC F223A, a mutant where the stacking of the aromatic rings of F7, adenine and F223 would be eliminated. The structure of this mutant with the ester shows that the ligand still maintains a syn conformation aided by pi-pi interactions to F7, hydrogen bonds to the backbone of Glu67, and electrostatic interactions. Several series of AdoMet substrate analogues with a variety of substituents at the 8 position of adenine were synthesized and analyzed for their ability to inhibit hAdoMetDC. To understand these results, virtual modeling of the enzyme inhibitor complexes and the crystal structures of human AdoMetDC with 5′-deoxy-5′-[N-methyl-N-[2-(aminooxy)ethyl]amino-8-methyl]adenosine (MAOEMA) and 5′-deoxy-5′-[N-methyl-N-[4-(aminooxy)butyl]amino-8-ethyl]adenosine (MAOBEA) at the active site have been determined experimentally.

  S-腺苷甲硫氨酸甲酯与hΛdoMetDC F223A复合物的晶体结构，其中F7，腺嘌呤和F223的芳香环堆叠被消除。该突变体与酯的结构表明，配体仍然通过与F7的pi-pi相互作用，与Glu67的背骨氢键和静电相互作用维持同步构象。合成了几系列具有不同取代基的腺嘌呤8位的AdoMet底物类似物，并分析了它们抑制hAdoMetDC的能力。为了理解这些结果，实验确定了酶抑制剂复合物和人类AdoMetDC与5'-去氧-5'-[N-甲基-N-[2-(氨氧)乙基]氨基-8-甲基]腺苷（MAOEMA）和5'-去氧-5'-[N-甲基-N-[4-(氨氧)丁基]氨基-8-乙基]腺苷（MAOBEA）在活性位点的晶体结构。
• 5',-SUBSTITUTED ADENOSYNES PREPARATION THEREOF AND USE AS INHIBITORS OF S-ADENOSYLMETHIONINE DECARBOXYLASE
  申请人：Secrist, III John A.

  公开号：US20110009354A1

  公开（公告）日：2011-01-13

  The crystal structure of the complex of S-adenosylmethionine methyl ester with hΛdoMetDC F223A, a mutant where the stacking of the aromatic rings of F7, adenine and F223 would be eliminated. The structure of this mutant with the ester shows that the ligand still maintains a syn conformation aided by pi-pi interactions to F7, hydrogen bonds to the backbone of Glu67, and electrostatic interactions. Several series of AdoMet substrate analogues with a variety of substituents at the 8 position of adenine were synthesized and analyzed for their ability to inhibit hAdoMetDC. To understand these results, virtual modeling of the enzyme inhibitor complexes and the crystal structures of human AdoMetDC with 5′-deoxy-5′-[N-methyl-N-[2-(aminooxy)ethyl]amino-8-methyl]adenosine (MAOEMA) and 5′-deoxy-5′-[N-methyl-N-[4-(aminooxy)butyl]amino-8-ethyl]adenosine (MAOBEA) at the active site have been determined experimentally.

  S-腺苷甲硫氨酸甲酯与hΛdoMetDC F223A复合物的晶体结构已被确定，该突变体中F7、腺嘌呤和F223的芳香环堆叠被消除。该突变体与酯的结构表明，配体仍通过与F7的π-π相互作用、与Glu67骨架的氢键和静电相互作用来维持同构构象。合成了几个AdoMet底物类似物系列，这些类似物在腺嘌呤的8位具有不同的取代基，分析它们抑制hAdoMetDC的能力。为了理解这些结果，通过虚拟建模酶抑制剂复合物和人类AdoMetDC与5'-去氧-5'-[N-甲基-N-[2-(氨氧)乙基]氨基-8-甲基]腺苷(MAOEMA)和5'-去氧-5'-[N-甲基-N-[4-(氨氧)丁基]氨基-8-乙基]腺苷(MAOBEA)在活性位点的晶体结构已被实验确定。
• 5'-substituted adenosynes, preparation thereof and use as inhibitors of s-adenosylmethionine decarboxylase.
  申请人：Southern Research Institute

  公开号：EP2574616A2

  公开（公告）日：2013-04-03

  The crystal structure of the complex of S-adenosylmethionine methyl ester with hAdoMetDC F223A, a mutant where the stacking of the aromatic rings of F7, adenine and F223 would be eliminated. The structure of this mutant with the ester shows that the ligand still maintains a syn conformation aided by pi-pi interactions to F7, hydrogen bonds to the backbone of Glu67, and electrostatic interactions. Several series of AdoMet substrate analogues with a variety of substituents at the 8 position of adenine were synthesized and analyzed for their ability to inhibit hAdoMetDC. To understand these results, virtual modeling of the enzyme inhibitor complexes and the crystal structures of human AdoMetDC with 5'-deoxy-5'-[N-methyl-N-[2-(aminooxy)ethyl]ainino-8-methyl]adenosine (MAOEMA) and 5'-deoxy-5'-[N-methyl-N-[4-(aminooxy)butyl]amino-8-ethyl]adenosine (MAOBEA) at the active site have been determined experimentally.

  S- 腺苷蛋氨酸甲酯与 hAdoMetDC F223A 复合物的晶体结构，F223A 是一种突变体，在这种突变体中，F7、腺嘌呤和 F223 的芳香环堆积将被消除。这种带有酯的突变体的结构显示，配体仍然通过与 F7 的 pi-pi 相互作用、与 Glu67 骨架的氢键以及静电作用保持合成构象。我们合成了几个系列的 AdoMet 底物类似物，它们在腺嘌呤的 8 位上有多种取代基，并分析了它们抑制 hAdoMetDC 的能力。为了理解这些结果，实验测定了酶抑制剂复合物的虚拟模型以及人 AdoMetDC 与 5'-脱氧-5'-[N-甲基-N-[2-（氨基氧）乙基]氨基-8-甲基]腺苷（MAOEMA）和 5'-脱氧-5'-[N-甲基-N-[4-（氨基氧）丁基]氨基-8-乙基]腺苷（MAOBEA）在活性位点的晶体结构。
• [EN] 5'-SUBSTITUTED ADENOSYNES, PREPARATION THEREOF AND USE AS INHIBITORS OF S-ADENOSYLMETHIONINE DECARBOXYLASE<br/>[FR] ADÉNOSYNES SUBSTITUÉES EN 5', PRÉPARATION DE CELLES-CI ET UTILISATION COMME INHIBITEUR DE LA S-ADÉNOSYLMÉTHIONINE DÉCARBOXYLASE
  申请人：SOUTHERN RES INST

  公开号：WO2009018541A8

  公开（公告）日：2010-03-04