4-hydroxy-2,2,6,6-tetramethylpiperidin-1-yl carbonic acid methyl ester | 1001081-00-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-yl carbonic acid methyl ester
• 英文别名: (4-Hydroxy-2,2,6,6-tetramethylpiperidin-1-yl) methyl carbonate
• CAS: 1001081-00-0
• 化学式: C₁₁H₂₁NO₄
• 分子量: 231.292
• InChiKey: LRZVDTCXTZWZMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  乙醛酸甲酯 、 阻聚剂701 在 双氧水 、 copper(l) chloride 作用下， 反应 13.0h， 以76%的产率得到4-hydroxy-2,2,6,6-tetramethylpiperidin-1-yl carbonic acid methyl ester
  参考文献：
  名称：

  Synthetic Studies on N-Alkoxyamines: A Mild and Broadly Applicable Route Starting from Nitroxide Radicals and Aldehydes

  摘要：

  A broad variety of 2,2,6,6-tetramethylpiperidine-based N-alkoxyamines were prepared in a newly found reaction. By means of a copper-catalyzed fragmentation reaction of aldehyde peroxides in the presence of TEMPO or TEMPO derivatives, N-alkoxyamines were obtained in moderate to good yields.

  DOI：

  10.1021/jo802403j

文献信息

• A Novel Method for the Synthesis of <i>N</i>-Alkoxyamines Starting from Nitroxide Radicals and Ketones
  作者：Kai-Uwe Schoening、Alexander Dichtl、Martin Seyfried

  DOI：10.1055/s-2008-1078526

  日期：——

  A new reaction for the conversion of stable nitroxide radicals into the corresponding N-alkoxyamines by means of a copper-catalyzed ketone-hydrogen peroxide reaction is reported.

  报道称，通过铜催化的酮-过氧化氢反应，实现稳定氮氧自由基向对应N-烷氧胺转化的全新反应途径已被发现。
• Process for the preparation of sterically hindered nitroxyl ethers
  申请人：Schöning Kai-Uwe

  公开号：US20100249401A1

  公开（公告）日：2010-09-30

  The present invention relates to a novel process for the preparation of a sterically hindered nitroxyl ether from the corresponding sterically hindered nitroxyl radical by reacting it with a carbonyl compound and a hydroperoxide. The compounds prepared by this process are effective stabilizers for polymers against harmful effects of light, oxygen and/or heat, as flame-retardants for polymers and as polymerization regulators.

  本发明涉及一种从相应的立体位阻的亚硝基自由基通过与羰基化合物和过氧化氢反应制备立体位阻的亚硝基醚的新工艺。通过该工艺制备的化合物是聚合物的有效稳定剂，可抵抗光、氧和/或热的有害影响，作为聚合物的阻燃剂和聚合物化合物的调节剂。
• PROCESS FOR THE PREPARATION OF STERICALLY HINDERED NITROXYL ETHERS
  申请人：BASF SE

  公开号：EP2035381B1

  公开（公告）日：2010-12-29
• US8471031B2
  申请人：——

  公开号：US8471031B2

  公开（公告）日：2013-06-25
• [EN] PROCESS FOR THE PREPARATION OF STERICALLY HINDERED NITROXYL ETHERS<br/>[FR] PROCÉDÉ DE PRÉPARATION D'ÉTHERS DE NITROXYLE STÉRIQUEMENT ENCOMBRÉS
  申请人：CIBA SC HOLDING AG

  公开号：WO2008003602A1

  公开（公告）日：2008-01-10

  [EN] The present invention relates to a novel process for the preparation of a sterically hindered nitroxyl ether from the corresponding sterically hindered nitroxyl radical by reacting it with a carbonyl compound and a hydroperoxide. The compounds prepared by this process are effective stabilizers for polymers against harmful effects of light, oxygen and/or heat, as flame-retardants for polymers and as polymerization regulators.
  [FR] La présente invention concerne un procédé innovant de préparation d'un éther de nitroxyle stériquement encombré à partir du radical nitroxyle stériquement encombré correspondant en le faisant réagir avec un composé de carbonyle et un hydropéroxyde. Les composés préparés par ce procédé sont des stabilisants efficaces pour les polymères contre les effets nuisibles de la lumière, de l'oxygène et/ou de la chaleur, en tant qu'ignifugeants pour les polymères et que régulateurs de polymérisation.