diacetonyl sulfoxide | 77694-47-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 亚砜
• 英文名称: diacetonyl sulfoxide
• 英文别名: 4-Oxo-4λ⁴-thia-heptan-2,6-dion；Diacetonyl-sulfoxid；1-(2-Oxopropylsulfinyl)propan-2-one
• CAS: 77694-47-4
• 化学式: C₆H₁₀O₃S
• 分子量: 162.21
• InChiKey: GLTAHYSWNBEXDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  70.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  diacetonyl sulfoxide 、 氨基硫脲 生成 [(E)-1-[(2E)-2-(carbamothioylhydrazinylidene)propyl]sulfinylpropan-2-ylideneamino]thiourea
  参考文献：
  名称：

  GANNON M.; MCELHINNEY R. S.; KESSEL D., PROC. ROY. IRISH ACAD., 1980, B80, NO 7-8, 107-116

  摘要：

  DOI：
• 作为产物：
  描述：

  4-thiaheptane-2,6-dione 在 双氧水 、 溶剂黄146 作用下， 生成 diacetonyl sulfoxide
  参考文献：
  名称：

  Bacchetti; Caprio, Gazzetta Chimica Italiana, 1953, vol. 83, p. 832,838

  摘要：

  DOI：

文献信息

• Natural and synthetic sulfur and selenium analogs and polymer conjugated forms thereof for the modulation of angiogenesis
  申请人：Mousa Shaker

  公开号：US20100080843A1

  公开（公告）日：2010-04-01

  The present invention relates to inhibiting angiogenesis with sulfur- or selenium-containing compounds, and polymeric forms thereof, in mammals including animals and humans. Sulfur- or selenium-containing compounds, and polymeric forms thereof, can be used alone or in combination with standard therapies to inhibit angiogenesis-mediated disorders. The present invention also relates to the combined use of sulfur- or selenium-containing compounds, and polymeric forms thereof, with other anti-angiogenesis agents, with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer, and with laser, photodynamic therapy for ocular-related disorders such as diabetic retinopathy or age-related macular degeneration.
• Bacchetti; Caprio, Gazzetta Chimica Italiana, 1953, vol. 83, p. 832,838
  作者：Bacchetti、Caprio

  DOI：——

  日期：——
• GANNON M.; MCELHINNEY R. S.; KESSEL D., PROC. ROY. IRISH ACAD., 1980, B80, NO 7-8, 107-116
  作者：GANNON M.、 MCELHINNEY R. S.、 KESSEL D.

  DOI：——

  日期：——