2-amino-4-methyl-5-phenylthiophene-3-carboxylic acid | 190062-95-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 2-amino-4-methyl-5-phenylthiophene-3-carboxylic acid
• 英文别名: 2-amino-5-phenyl-4-methylthiophene-3-carboxylic acid；2-Amino-4-methyl-5-phenyl-3-thiophenecarboxylic acid
• CAS: 190062-95-4
• 化学式: C₁₂H₁₁NO₂S
• 分子量: 233.291
• InChiKey: CHWCLEYHFNQSSK-UHFFFAOYSA-N

物化性质

• 熔点：
  153 °C
• 沸点：
  424.6±45.0 °C(Predicted)
• 密度：
  1.330±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  91.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-amino-4-methyl-5-phenylthiophene-3-carboxylic acid 、 氯甲酸乙酯 在 potassium carbonate 、 sodium hydroxide 作用下， 以 乙腈 、 氯仿 为溶剂， 以8%的产率得到ethyl 4-methyl-5-phenylthiophen-2-ylcarbamate
  参考文献：
  名称：

  Substituted 2-Aminothiopen-derivatives: A potential new class of GluR6-Antagonists

  摘要：

  In the course of search for new therapeutic agents against epilepsy new inhibitors for the kainate receptor subtypes GluR5 and GluR6 were synthesized.We were able to synthesize new substituted thieno[2,3-d]pyrimidines 3a,b, 4a,b, Sa,b as well as thiophene-3-carboxamides 2a-d and a multitude of substituted 4-methyl-5-phenylthiophene-3-carboxylic acids.All compounds described herein were tested for their antagonistic effect towards the kainate receptor subtypes GluR5 and GluR6. The highest activity was observed for ethyl 2-amino-4-methyl-5-phenylthiophene-3-carboxylate 1c with an IC50 = 0.75 mu M at the GluR6 receptor. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.09.025
• 作为产物：
  描述：

  2-氨基-4-甲基-5-苯基噻吩-3-羧酸乙酯 在 水 、 sodium hydroxide 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 2.5h， 以83%的产率得到2-amino-4-methyl-5-phenylthiophene-3-carboxylic acid
  参考文献：
  名称：

  Substituted 2-Aminothiopen-derivatives: A potential new class of GluR6-Antagonists

  摘要：

  In the course of search for new therapeutic agents against epilepsy new inhibitors for the kainate receptor subtypes GluR5 and GluR6 were synthesized.We were able to synthesize new substituted thieno[2,3-d]pyrimidines 3a,b, 4a,b, Sa,b as well as thiophene-3-carboxamides 2a-d and a multitude of substituted 4-methyl-5-phenylthiophene-3-carboxylic acids.All compounds described herein were tested for their antagonistic effect towards the kainate receptor subtypes GluR5 and GluR6. The highest activity was observed for ethyl 2-amino-4-methyl-5-phenylthiophene-3-carboxylate 1c with an IC50 = 0.75 mu M at the GluR6 receptor. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.09.025

文献信息

• Thieno[2,3-d]pyrimidines and -[1,3]oxazines as glutamate antagonists and investigations on the inhibitory potency toward human leukocyte elastase
  作者：Detlef Briel、Anastasiya Rybak、Christiane Kronbach、Klaus Unverferth、Camino M. González Tanarro、Michael Gütschow

  DOI：10.1002/jhet.375

  日期：——

  Thieno[2,3‐d][1, 3]oxazin‐4‐one 2 (R = C2H5) was identified as new a potent inhibitor (IC50 = 17 μM) of this receptor subtype. The inhibitory potency of 2 (R = C2H5) against human leukocyte elastase was also examined. The compound was characterized as a noncovalent inhibitor with an IC50 value of 8.8 μM. J. Heterocyclic Chem., (2010).

  一系列稠合的噻吩衍生物，即，噻吩并[2,3-代表d ]嘧啶，噻吩并[2,3- d ] [ 1，3 ]恶嗪和噻吩并[2,3- d ] [ 1，3 ]合成了具有共同的5-甲基-6-苯基取代模式的噻嗪。目标化合物，例如，7或8，被设计为2-氨基-4-甲基-5-苯基噻吩-3-羧酸乙酯，在GluR6红藻氨酸受体的拮抗剂的环状类似物。噻吩并[2,3- d ] [ 1，3 ]恶嗪-4-酮2（R = C 2 H ^5）被确定为新的强效抑制剂（IC 50 = 17μ中号这个受体亚型的）。还检查了对人白细胞弹性蛋白酶的抑制力2（R = C 2 H 5）。将该化合物表征为具有IC非共价抑制剂50 8.8μ值中号。J.杂环化​​学。（2010）。
• Prolactin production inhibitory agents
  申请人：TAKEDA CHEMICAL INDUSTRIES, LTD.

  公开号：EP0781774A2

  公开（公告）日：1997-07-02

  The prolactin production inhibition agent of the present invention containing a condensed cyclic compound, which is characterized by containing a condensed bicyclic structure of an optionally substituted homo or hetero 5- to 7-membered ring with an optionally substituted homo or hetero 5- to 7-membered ring, or a salt thereof, can be used, as a medicine, for the prophylaxis or therapy of diseases accompanied with an excess prolactin production or diseases having enhanced reactivity with prolactin, or is useful for inhibiting puerperal lactation, and also useful as a prophylactic or therapeutic agent of galactorrhea, hyperprolactinemic ovulation disturbance, amenorrheagalactorrhea syndrome, prolactinoma, and besides, interbrain tumor, and acromegaly, pituitary gigantism.

  本发明的催乳素分泌抑制剂含有缩合环状化合物，其特征在于该化合物含有一个由任选取代的同族或杂族 5 至 7 元环与一个任选取代的同族或杂族 5 至 7 元环组成的缩合双环结构，或其盐，可用作药物、可用于预防或治疗伴有催乳素分泌过多的疾病或与催乳素反应性增强的疾病，也可用于抑制产褥期泌乳，还可用作半乳糖性闭经、高催乳素血症排卵障碍、闭经滞乳综合征、催乳素瘤的预防或治疗药物，此外还可用于脑间肿瘤、肢端肥大症、垂体巨大症。
• THIENOPYRIDINE DERIVATIVES AS GONADOTROPIN RELEASING HORMONE ANTAGONISTS
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0862573A1

  公开（公告）日：1998-09-09
• COMBINED USE OF GnRH AGONIST AND ANTAGONIST
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0906115A1

  公开（公告）日：1999-04-07
• PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE
  申请人：F.Hoffmann-La Roche AG

  公开号：EP2794616A1

  公开（公告）日：2014-10-29