4-[4-(5-chloro-thiophen-2-yl)-phenyl]-4-hydroxyimino-butyric acid | 1346808-52-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 4-[4-(5-chloro-thiophen-2-yl)-phenyl]-4-hydroxyimino-butyric acid
• 英文别名: (4E)-4-[4-(5-chlorothiophen-2-yl)phenyl]-4-hydroxyiminobutanoic acid
• CAS: 1346808-52-3
• 化学式: C₁₄H₁₂ClNO₃S
• 分子量: 309.773
• InChiKey: IMZHVSLZRORXCT-LFIBNONCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  98.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-[4-(5-chloro-thiophen-2-yl)-phenyl]-4-oxo-butyric acid 在 盐酸羟胺 、 sodium carbonate 作用下， 以 甲醇 、 乙醇 、 水 为溶剂， 生成 4-[4-(5-chloro-thiophen-2-yl)-phenyl]-4-hydroxyimino-butyric acid
  参考文献：
  名称：

  Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases

  摘要：

  本文介绍了杂环丁酸衍生物及其衍生物，以及其制备方法和药物组成物，它们可用作基质金属蛋白酶的抑制剂，特别是明胶酶A、胶原酶-3和基质金属蛋白酶-1，并用于治疗多发性硬化症、动脉粥样硬化斑块破裂、主动脉瘤、心力衰竭、再狭窄、牙周病、角膜溃疡、烧伤治疗、褥疮、伤口愈合、癌症、炎症、关节炎、骨质疏松症或其他依赖于白细胞或其他活化迁移细胞侵袭组织的自身免疫或炎症性疾病，急性和慢性神经退行性疾病，包括中风、头部创伤、脊髓损伤、阿尔茨海默病、肌萎缩侧索硬化、脑淀粉样血管病、艾滋病、帕金森病、亨廷顿病、朊病、重症肌无力和杜兴肌肉萎缩症的治疗。

  公开号：

  US06399612B1

文献信息

• US6399612B1
  申请人：——

  公开号：US6399612B1

  公开（公告）日：2002-06-04
• [EN] HETEROARYL BUTYRIC ACIDS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES<br/>[FR] ACIDES HETEROARYLE BUTURIQUES ET LEURS DERIVES EN TANT QU'INHIBITEURS DE METALLOPROTEINASES MATRICIELLES
  申请人：WARNER-LAMBERT COMPANY

  公开号：WO1999018079A1

  公开（公告）日：1999-04-15

  (EN) Heteroaryl butyric acid compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, osteoporosis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.(FR) L'invention concerne des composés et des dérivés d'acides hétéroaryle butyriques ainsi que leurs méthodes de préparation et compositions pharmaceutiques, lesquels sont utiles en tant qu'inhibiteurs de métalloprotéinases matricielles, notammemnt la gélatinase A, la collagénase-3 et la stromélysine-1 et dans le traitement de la sclérose en plaques, de la rupture de plaques athéroscléreuses, de l'anévrisme de l'aorte, de l'insuffisance cardiaque, de la resténose, de maladies desmodontales, de l'ulcération de la cornée, le traitement de brûlures, de l'escarre de décubitus, pour la cicatrisation des lésions, du cancer, de l'inflammation, de la douleur, de l'arthrite, de l'ostéoporose ainsi que d'autres maladies auto-immunes ou inflammatoires dépendantes de l'invasion tissulaire par les leucocytes ou autres cellules migrantes activées, également dans le traitement de maladies neurodégénératives aigües et chroniques notamment l'ictus, le trauma de la tête, les lésions de la moelle épinière, la maladie d'Alzheimer, la sclérose latérale amyotrophique, l'angiopathie amyloïde cérébrale, le SIDA, la maladie de Parkinson, la chorée de Huntington, les encéphalites spongiformes subaiguës, la myasthénie grave, et la distrophie musculaire progressive type Duchenne.
• Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
  申请人：Warner-Lambert Company

  公开号：US06399612B1

  公开（公告）日：2002-06-04

  Heteroaryl butyric acid compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, osteoporosis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.

  本文介绍了杂环丁酸衍生物及其衍生物，以及其制备方法和药物组成物，它们可用作基质金属蛋白酶的抑制剂，特别是明胶酶A、胶原酶-3和基质金属蛋白酶-1，并用于治疗多发性硬化症、动脉粥样硬化斑块破裂、主动脉瘤、心力衰竭、再狭窄、牙周病、角膜溃疡、烧伤治疗、褥疮、伤口愈合、癌症、炎症、关节炎、骨质疏松症或其他依赖于白细胞或其他活化迁移细胞侵袭组织的自身免疫或炎症性疾病，急性和慢性神经退行性疾病，包括中风、头部创伤、脊髓损伤、阿尔茨海默病、肌萎缩侧索硬化、脑淀粉样血管病、艾滋病、帕金森病、亨廷顿病、朊病、重症肌无力和杜兴肌肉萎缩症的治疗。