3-(3-氯苯基)哌嗪-1-羧酸叔丁酯 | 886767-41-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 3-(3-氯苯基)哌嗪-1-羧酸叔丁酯
• 英文名称: tert-butyl 3-(3-chlorophenyl)piperazine-1-carboxylate
• 英文别名: tert-Butyl 3-(3-chlorophenyl)piperazine-1-carboxylate
• CAS: 886767-41-5
• 化学式: C₁₅H₂₁ClN₂O₂
• mdl: MFCD08686004
• 分子量: 296.797
• InChiKey: NLCGGRDOWINSEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.533
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] ANTAGONISTS OF GPR39 PROTEIN<br/>[FR] ANTAGONISTES DE LA PROTÉINE GPR39
  申请人：UNIV OREGON HEALTH & SCIENCE

  公开号：WO2021222858A1

  公开（公告）日：2021-11-04

  Novel compounds that act as antagonists to human GPR39 protein are disclosed. Pharmaceutical compositions and methods of use for antagonists to human GPR39 protein are disclosed. In particular, methods of using the antagonists in the treatment of diseases or conditions including cardiovascular conditions, endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, neurological disorders and respiratory diseases are disclosed herein.