Diamocaine cyclamate | 23469-05-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Diamocaine cyclamate
• 英文别名: cyclohexylsulfamic acid;N-[2-[4-[2-(diethylamino)ethoxy]-4-phenylpiperidin-1-yl]ethyl]aniline
• CAS: 23469-05-8
• 化学式: C37H63N5O7S2
• 分子量: 754.1
• InChiKey: WUYFDJKTIHVLQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.87
• 重原子数：
  51
• 可旋转键数：
  15
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  177
• 氢给体数：
  5
• 氢受体数：
  12

文献信息

• TERPENE COUPLING CONJUGATE
  申请人：LABORATOIRES ERIGER

  公开号：US20210361771A1

  公开（公告）日：2021-11-25

  The subject matter of the present invention relates to the use of an optionally branched linear terpene having at most one C═C unsaturation for the production of conjugates provided with self-assembly properties, as well as a self-assembly agent of formula (I): X(-Spacer-Y-Terpene) p (I) in which: “Terpene” is linear, optionally branched, having at most one C═C unsaturation; “Y” is a bond or a molecular fragment with a biodegradable bond; “Spacer” is a bond or a fragment comprising at least one carbon atom; “X” is a molecular fragment comprising at least one biodegradable bond; “p” ranges between 0.1 and 4; and the “-Spacer-Y-” group optionally can be a bond, as well as the conjugate resulting from the combination of the self-assembly agent of formula (I) with an active molecule MA.

  本发明的主题涉及使用最多具有一个C═C不饱和度的线性可选择分支的萜烯，用于具有自组装特性的共轭物的生产，以及具有以下式(I)的自组装剂： X(-Spacer-Y-Terpene) p (I) 其中： “萜烯”是线性的，可选择分支的，最多具有一个C═C不饱和度； “Y”是一个具有可生物降解键的键或分子片段； “Spacer”是一个包含至少一个碳原子的键或片段； “X”是一个包含至少一个可生物降解键的分子片段； “p”范围在0.1至4之间；以及 “-Spacer-Y-”基团可以选择是一个键， 以及由式(I)的自组装剂与活性分子MA的组合产生的共轭物。
• [EN] PRODRUG COMPOSITIONS AND METHODS OF TREATMENT<br/>[FR] COMPOSITIONS DE PROMÉDICAMENT ET PROCÉDÉS DE TRAITEMENT
  申请人：AQUESTIVE THERAPEUTICS INC

  公开号：WO2021087359A1

  公开（公告）日：2021-05-06

  Pharmaceutical compositions include a prodrug of epinephrine are described.

  药物组合物包括表述的肾上腺素前药。
• Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients
  申请人：Rogers D. Robin

  公开号：US20070093462A1

  公开（公告）日：2007-04-26

  Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.

  揭示了离子液体及制备活性药物、生物、营养和能量成分的离子液体组合物的方法。还揭示了利用本文描述的组合物的方法，以克服多型性、克服溶解度和输送问题、控制释放速率、增加功能性、增强功效（协同作用）以及改善易用性和制造工艺。
• [EN] DUAL FUNCTIONING IONIC LIQUIDS AND SALTS THEREOF<br/>[FR] LIQUIDES IONIQUES À DOUBLE FONCTION ET SELS DE CEUX-CI
  申请人：UNIV ALABAMA

  公开号：WO2010078300A1

  公开（公告）日：2010-07-08

  Disclosed herein are ionic liquid compositions comprising active pharmaceutical, biological, and nutritional compounds, and methods of use. Further disclosed are compositions of matter including liquid ion pairs alone or in solution and their use; compositions of ionic liquids that are 'solvated,' for example, 'hydrated' and their uses.

  本文揭示了包括活性药物、生物学和营养化合物的离子液体组合物，以及其使用方法。进一步揭示了包括液态离子对的物质组合物，单独或溶解后使用；以及离子液体的“溶剂化”组合物，例如“水合”的组合物及其用途。
• Wound Dressings, Methods of Using the Same and Methods of Forming the Same
  申请人：Stasko Nathan

  公开号：US20120136323A1

  公开（公告）日：2012-05-31

  Provided according to some embodiments of the invention are wound dressings that include a polymer matrix and nitric oxide-releasing polysiloxane macromolecules within and/or on the polymer matrix. Also provided are wound dressing kits and methods of using and forming such wound dressings.

  根据本发明的某些实施例，提供了包括聚合物基质和硅氧烷聚合物中释放一氧化氮的大分子的敷料。还提供了创伤敷料套件和使用和形成这种创伤敷料的方法。