(4-methylpiperazin-1-yl)(pyridin-4-yl)methanethione | 1429057-95-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (4-methylpiperazin-1-yl)(pyridin-4-yl)methanethione
• 英文别名: (4-Methylpiperazin-1-yl)-pyridin-4-ylmethanethione；(4-methylpiperazin-1-yl)-pyridin-4-ylmethanethione
• CAS: 1429057-95-3
• 化学式: C₁₁H₁₅N₃S
• 分子量: 221.326
• InChiKey: AEDBLOSOEGLMPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  51.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吗啉 、 罗丹宁 、 1-isonicotinoyl-4-methyl-piperazine 在 MCM-41 mesoporous silica 作用下， 以 乙醇 、 水 为溶剂， 反应 12.0h， 以71%的产率得到(4-methylpiperazin-1-yl)(pyridin-4-yl)methanethione
  参考文献：
  名称：

  A new application of rhodanine as a green sulfur transferring agent for a clean functional group interconversion of amide to thioamide using reusable MCM-41 mesoporous silica

  摘要：

  A novel thionation protocol for amide compounds, with the system rhodanine/secondary amine has been discovered. Clean and efficient synthesis of a variety of thioamides can be achieved through this simple and convenient method using MCM-41 mesoporous silica as an acid catalyst. For this purpose we have synthesized MCM-41 silica and characterized by using an array of sophisticated analytical techniques like BET, HR TEM, EDX, XRD, 29Si MAS NMR and FTIR. This reaction is therefore a very neat example of a functional group interconversion. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.02.045

文献信息

• A new application of rhodanine as a green sulfur transferring agent for a clean functional group interconversion of amide to thioamide using reusable MCM-41 mesoporous silica
  作者：Suman Ray、Asim Bhaumik、Arghya Dutta、Ray J. Butcher、Chhanda Mukhopadhyay

  DOI：10.1016/j.tetlet.2013.02.045

  日期：2013.4

  A novel thionation protocol for amide compounds, with the system rhodanine/secondary amine has been discovered. Clean and efficient synthesis of a variety of thioamides can be achieved through this simple and convenient method using MCM-41 mesoporous silica as an acid catalyst. For this purpose we have synthesized MCM-41 silica and characterized by using an array of sophisticated analytical techniques like BET, HR TEM, EDX, XRD, 29Si MAS NMR and FTIR. This reaction is therefore a very neat example of a functional group interconversion. (C) 2013 Elsevier Ltd. All rights reserved.