4-(1-Methyl-ethyl)-thiophen-2-carbonsaeure | 79602-58-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 4-(1-Methyl-ethyl)-thiophen-2-carbonsaeure
• 英文别名: 4-isopropylthiophene-2-carboxylic acid；4-isopropyl-thiophene-2-carboxylic acid；4-Isopropyl-thiophen-2-carbonsaeure；2-Carboxy-4-isopropylthiophen；4-propan-2-ylthiophene-2-carboxylic acid
• CAS: 79602-58-7
• 化学式: C₈H₁₀O₂S
• 分子量: 170.232
• InChiKey: VFZFHLPZEOBVTG-UHFFFAOYSA-N

物化性质

• 熔点：
  92-93 °C
• 沸点：
  293.9±28.0 °C(Predicted)
• 密度：
  1.202±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(1-Methyl-ethyl)-thiophen-2-carbonsaeure 在 sodium hydroxide 、 nickel-aluminium 作用下， 生成 4,5-dimethylhexanoic acid
  参考文献：
  名称：

  Friedel-Crafts Isopropylation of Methyl 2-Thienyl Ketone^1a

  摘要：

  DOI：

  10.1021/ja01620a030
• 作为产物：
  描述：

  3-isopropylthiophene 在 sodium hypochlorite 作用下， 生成 4-(1-Methyl-ethyl)-thiophen-2-carbonsaeure
  参考文献：
  名称：

  Friedel-Crafts Isopropylation of Methyl 2-Thienyl Ketone^1a

  摘要：

  DOI：

  10.1021/ja01620a030

文献信息

• Substituted bis-amide metalloprotease inhibitors
  申请人：Sucholeiki Irving

  公开号：US20070155739A1

  公开（公告）日：2007-07-05

  This invention relates to substituted bis-amide pyrimidine compounds of Formula (I), which are useful for the treatment of metalloprotease mediated diseases, in particular MMP-13 related diseases.

  这项发明涉及Formula (I)的取代双酰胺嘧啶化合物，这些化合物对于治疗金属蛋白酶介导的疾病，特别是MMP-13相关疾病是有用的。
• SUBSTITUTED VINYL AND ALKINYL CYCLOHEXENOLS AS ACTIVE AGENTS AGAINST ABIOTIC STRESS IN PLANTS
  申请人：Frackenpohl Jens

  公开号：US20140080704A1

  公开（公告）日：2014-03-20

  The invention relates to substituted vinyl- and alkynylcyclohexenols of the general formula (I) and salts thereof where the R 1 , R 2 , R 3 , R 4 , R 5 , [X—Y] and Q radicals are each as defined in the description, to processes for preparation thereof and to the use thereof for enhancing stress tolerance in plants with respect to abiotic stress, and/or for increasing plant yield.

  该发明涉及通式（I）中的取代乙烯基和炔基环己烯醇及其盐，其中R1、R2、R3、R4、R5、[X—Y]和Q基团如描述中所定义，以及其制备方法和用途，用于增强植物对非生物胁迫的抗逆性，和/或增加植物产量。
• SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS
  申请人：PLAYER Mark R.

  公开号：US20110218197A1

  公开（公告）日：2011-09-08

  The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

  本发明涉及替代的氮杂双环咪唑衍生物，含有它们的药物组合物以及它们在治疗由TRP M8调节的疾病和症状中的用途，包括但不限于炎症性疼痛、炎症性过敏症、炎症性过敏性疾病、神经病性疼痛、神经性寒冷痛觉过敏、炎症性体感过敏、炎症性内脏过敏、受寒加重的心血管疾病和受寒加重的肺部疾病。
• Heterobicyclic metalloprotease inhibitors
  申请人：Bluhm Harald

  公开号：US20080221092A1

  公开（公告）日：2008-09-11

  The present invention relates generally to amide containing heterobicyclic containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-3 and/or MMP-13 inhibiting compounds that exhibit an increased potency and selectivity in relation to currently known MMP-13 and MMP-3 inhibitors.

  本发明通常涉及含有酰胺的杂双环含有药物作用的化合物，特别地，涉及含有酰胺的杂双环金属蛋白酶抑制剂。更具体地，本发明提供了一类新型的杂双环MMP-3和/或MMP-13抑制剂化合物，相对于目前已知的MMP-13和MMP-3抑制剂，这些化合物表现出更高的效力和选择性。
• Compounds
  申请人：Alcaraz Lilian

  公开号：US20090298807A1

  公开（公告）日：2009-12-03

  The present invention relates to spirocyclic amide derivatives of the formula I, pharmaceutically acceptable salts thereof, a process for their preparation, pharmaceutical compositions containing them, and their use in therapy.

  本发明涉及公式 I 的螺环酰胺衍生物，其药学上可接受的盐，其制备方法，含有它们的制药组合物以及它们在治疗中的应用。