3-(5-甲基噻吩-2-基)环庚酮 | 1000883-82-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 中文名称: 3-(5-甲基噻吩-2-基)环庚酮
• 英文名称: 3-(5-methylthiophen-2-yl)cycloheptanone
• 英文别名: 3-(5-Methylthiophen-2-yl)cycloheptan-1-one
• CAS: 1000883-82-8
• 化学式: C₁₂H₁₆OS
• 分子量: 208.324
• InChiKey: CIKBYMMLJPWTHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  45.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-甲基噻吩 、 2-环庚烯-1-酮 在 vanadyl triflate 作用下， 以 二氯甲烷 为溶剂， 反应 36.0h， 以85%的产率得到3-(5-甲基噻吩-2-基)环庚酮
  参考文献：
  名称：

  Catalytic Conjugate Additions of Nitrogen-, Phosphorus-, and Carbon-Containing Nucleophiles by Amphoteric Vanadyl Triflate

  摘要：

  A series of carbamates, amides, N-tosyl amides, (hetero)arenes, and hydrogen phosphines/phosphites has been examined as nucleophiles for (hetero)Michael-type additions to enones and enamides catalyzed by amphoteric vanadyl triflate under mild and neutral conditions. The newly developed C-N, C-P, and C-C bond-formation protocols were carried out smoothly in good to high yields without intervention of any 1,2-additions.

  DOI：

  10.1021/ol702302y

文献信息

• Catalytic Conjugate Additions of Nitrogen-, Phosphorus-, and Carbon-Containing Nucleophiles by Amphoteric Vanadyl Triflate
  作者：Yow-Dzer Lin、Jun-Qi Kao、Chien-Tien Chen

  DOI：10.1021/ol702302y

  日期：2007.12.1

  A series of carbamates, amides, N-tosyl amides, (hetero)arenes, and hydrogen phosphines/phosphites has been examined as nucleophiles for (hetero)Michael-type additions to enones and enamides catalyzed by amphoteric vanadyl triflate under mild and neutral conditions. The newly developed C-N, C-P, and C-C bond-formation protocols were carried out smoothly in good to high yields without intervention of any 1,2-additions.