Vex3BL2H9X | 805240-76-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: Vex3BL2H9X
• 英文别名: [2,3-dichloro-4-[4-[4-[(2-oxo-3,4-dihydro-1H-quinolin-7-yl)oxy]butyl]piperazin-1-yl]phenyl] hydrogen sulfate
• CAS: 805240-76-0
• 化学式: C₂₃H₂₇Cl₂N₃O₆S
• 分子量: 544.4
• InChiKey: XGSPNQWLRVBZIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Carbostyril derivatives and mood stabilizers for treating mood disorders
  申请人：Kikuchi Tetsuro

  公开号：US20070031513A1

  公开（公告）日：2007-02-08

  The pharmaceutical composition of the present invention comprises a carbostyril derivative which is a dopamine-sero-tonin system stabilizer and a mood stabilizer in a pharmaceutically acceptable carrier. The carbostyril derivative may be aripiprazole or a metabolite thereof. The mood stabilizer may include but is not limited to lithium, valproic acid, divalproex sodium, carbamaza-pine, oxcarbamazapine, zonisamide, lamotragine, topiramate, gabapentin, levetiracetam or clonazepam. These compositions are used to treat patients with mood disorders, particularly bipolar disorder with or without psychotic features, mania or mixed episodes. Methods are provided for separate administration of a carbostyril derivative and a mood stabilizer to a patient with a mood disorder.

  本发明的制药组合物包括一种卡波司吡啶衍生物，该衍生物是一种多巴胺-5-羟色胺系统稳定剂和情绪稳定剂，以及一种在药学上可接受的载体。卡波司吡啶衍生物可以是阿立哌唑或其代谢物。情绪稳定剂可以包括但不限于锂、丙戊酸、二乙酰氧基钠、卡马西平、奥卡西平、佐尼酰胺、拉莫三嗪、托吡酯、加巴喷丁、左乙拉西坦或氯硝西泮。这些组合物用于治疗情绪障碍患者，特别是具有或不具有精神病特征的双相情感障碍、躁狂或混合发作。提供了将卡波司吡啶衍生物和情绪稳定剂分别给予情绪障碍患者的方法。
• CARBOSTYRIL DERIVATIVES AND MOOD STABILIZERS FOR TREATING MOOD DISORDERS
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：US20160030423A1

  公开（公告）日：2016-02-04

  The pharmaceutical composition of the present invention comprises a carbostyril derivative which is a dopamine-serotonin system stabilizer and a mood stabilizer in a pharmaceutically acceptable carrier. The carbostyril derivative may be aripiprazole or a metabolite thereof. The mood stabilizer may include but is not limited to lithium, valproic acid, divalproex sodium, carbamazapine, oxcarbamazapine, zonisamide, lamotragine, topiramate, gabapentin, levetiracetam or clonazepam. These compositions are used to treat patients with mood disorders, particularly bipolar disorder with or without psychotic features, mania or mixed episodes. Methods are provided for separate administration of a carbostyril derivative and a mood stabilizer to a patient with a mood disorder.

  本发明的药物组合物包括一种卡波斯替利衍生物，该衍生物是一种多巴胺-5-羟色胺系统稳定剂和情绪稳定剂，以及一种药学上可接受的载体。该卡波斯替利衍生物可以是阿立哌唑或其代谢物。情绪稳定剂可以包括但不限于锂、丙戊酸、二丙戊酸钠、卡马西平、奥卡西平、佐尼酰胺、拉莫三嗪、托吡酯、加巴喷丁、左乙拉西坦或氯硝西泮。这些组合物被用于治疗情绪障碍患者，特别是具有或不具有精神病特征的双相情感障碍、躁狂或混合发作。本发明还提供了将卡波斯替利衍生物和情绪稳定剂分别给患有情绪障碍的患者的方法。
• US9125939B2
  申请人：——

  公开号：US9125939B2

  公开（公告）日：2015-09-08