(Z)-(2,4-dinitrophenoxy)imino-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-oxidoazanium | 903568-75-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (Z)-(2,4-dinitrophenoxy)imino-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-oxidoazanium
• CAS: 903568-75-2
• 化学式: C₁₅H₂₀N₆O₈
• 分子量: 412.359
• InChiKey: ZRUCZZBKQMVVJB-PGMHBOJBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  175
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  (Z)-(2,4-dinitrophenoxy)imino-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-oxidoazanium 在 盐酸 作用下， 以 乙酸乙酯 为溶剂， 生成 (Z)-(2,4-dinitrophenoxy)imino-oxido-piperazin-4-ium-1-ylazanium;chloride
  参考文献：
  名称：

  Synthesis and in vitro anti-leukemic activity of structural analogues of JS-K, an anti-cancer lead compound

  摘要：

  Structural analogues of JS-K, an anti-cancer lead compound, were prepared and their in vitro anti-leukemic activity was determined. The rate of nitric oxide release from the corresponding diazeniumdiolate anions did not appear to affect the anti-leukemic activity of the prodrug forms. Two compounds with potent inhibitory activity and a potentially favorable toxicological profile were identified. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.12.044
• 作为产物：
  描述：

  sodium 1-[4-(tert-butoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate 、 2,4-二硝基氟苯 在 碳酸氢钠 作用下， 以 叔丁醇 为溶剂， 反应 24.0h， 生成 (Z)-(2,4-dinitrophenoxy)imino-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-oxidoazanium
  参考文献：
  名称：

  Antitumor Activity of JS-K [O²-(2,4-Dinitrophenyl) 1-[(4-Ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] and Related O²-Aryl Diazeniumdiolates in Vitro and in Vivo

  摘要：

  The literature provides evidence that metabolic nitric oxide ( NO) release mediates the cytotoxic activities ( against human leukemia and prostate cancer xenografts in mice) of JS-K, a compound of structure R2N-(O)=NO-Ar for which R2N is 4-(ethoxycarbonyl) piperazin-1-yl and Ar is 2,4-dinitrophenyl. Here we present comparative data on the potencies of JS-K and 41 other O-2-arylated diazeniumdiolates as inhibitors of HL-60 human leukemia cell proliferation, as well as in the NCI 51-cell-line screen for six of them. The data show JS-K to be the most potent of the 42 in both screens and suggest that other features of its structure and metabolism besides NO release may contribute importantly to its activity. Results with control compounds implicate JS-K's arylating ability, and the surprisingly low IC50 value of the N-(ethoxycarbonyl) piperazine byproduct of NO release suggests a role for the R2N moiety. In addition to the above-mentioned in vivo activities, JS-K is shown here to be carcinostatic in a rat liver cancer model.

  DOI：

  10.1021/jm060022h

文献信息

• Antitumor Activity of JS-K [<i>O</i>²-(2,4-Dinitrophenyl) 1-[(4-Ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] and Related <i>O</i>²-Aryl Diazeniumdiolates in Vitro and in Vivo
  作者：Paul J. Shami、Joseph E. Saavedra、Challice L. Bonifant、Jingxi Chu、Vidya Udupi、Swati Malaviya、Brian I. Carr、Siddhartha Kar、Meifeng Wang、Lee Jia、Xinhua Ji、Larry K. Keefer

  DOI：10.1021/jm060022h

  日期：2006.7.1

  The literature provides evidence that metabolic nitric oxide ( NO) release mediates the cytotoxic activities ( against human leukemia and prostate cancer xenografts in mice) of JS-K, a compound of structure R2N-(O)=NO-Ar for which R2N is 4-(ethoxycarbonyl) piperazin-1-yl and Ar is 2,4-dinitrophenyl. Here we present comparative data on the potencies of JS-K and 41 other O-2-arylated diazeniumdiolates as inhibitors of HL-60 human leukemia cell proliferation, as well as in the NCI 51-cell-line screen for six of them. The data show JS-K to be the most potent of the 42 in both screens and suggest that other features of its structure and metabolism besides NO release may contribute importantly to its activity. Results with control compounds implicate JS-K's arylating ability, and the surprisingly low IC50 value of the N-(ethoxycarbonyl) piperazine byproduct of NO release suggests a role for the R2N moiety. In addition to the above-mentioned in vivo activities, JS-K is shown here to be carcinostatic in a rat liver cancer model.
• Synthesis and in vitro anti-leukemic activity of structural analogues of JS-K, an anti-cancer lead compound
  作者：Harinath Chakrapani、Michael M. Goodblatt、Vidya Udupi、Swati Malaviya、Paul J. Shami、Larry K. Keefer、Joseph E. Saavedra

  DOI：10.1016/j.bmcl.2007.12.044

  日期：2008.2

  Structural analogues of JS-K, an anti-cancer lead compound, were prepared and their in vitro anti-leukemic activity was determined. The rate of nitric oxide release from the corresponding diazeniumdiolate anions did not appear to affect the anti-leukemic activity of the prodrug forms. Two compounds with potent inhibitory activity and a potentially favorable toxicological profile were identified. (C) 2007 Elsevier Ltd. All rights reserved.