50SF8H9Dcz | 849105-26-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 50SF8H9Dcz
• 英文别名: (4S)-4-(4-chlorophenyl)-1-[(3E)-3-[9-(2-hydroxypropan-2-yl)-5H-[1]benzoxepino[3,4-b]pyridin-11-ylidene]propyl]-3,3-dimethylpiperidin-4-ol
• CAS: 849105-26-6
• 化学式: C₃₂H₃₇ClN₂O₃
• 分子量: 533.1
• InChiKey: ZGFJFBOLVLFLLN-MOLVWPNASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  38
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  65.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：US20160031908A1

  公开（公告）日：2016-02-04

  Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.

  揭示了新颖的化合物以及治疗与异常白细胞召集和/或激活相关的疾病的方法。该方法包括向需要的受试者施用代表的化合物的有效量： 或其生理上可接受的盐。
• Chemokine receptor antagonists and methods of use thereof
  申请人：Luly R. Jay

  公开号：US20050070549A1

  公开（公告）日：2005-03-31

  Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof.

  揭示了新化合物和一种治疗与异常白细胞召集和/或激活相关疾病的方法。该方法包括向需要的受试者施用由以下公式（1）表示的化合物或其生理上可接受的盐的有效量。
• [EN] PROCESS IMPROVEMENT<br/>[FR] AMÉLIORATION DE PROCESSUS
  申请人：MILLENNIUM PHARM INC

  公开号：WO2009070556A1

  公开（公告）日：2009-06-04

  An improved chemical synthesis for intermediates of compounds having useful biological activity is disclosed, where the use of PBr3 is employed as a reagent for a selective ring opening of cyclopropylcarbinols to give bromopropylidene products which are highly selectively the E isomer.

  本发明公开了一种改进的化学合成方法，用于合成具有有用生物活性的化合物的中间体。该方法采用PBr3作为试剂，对环丙基醇进行选择性开环反应，生成高度选择性的E异构体溴丙烯基产物。
• [EN] PROCESS FOR THE PREPARATION OF 5-CYCLOPROPYL-5, 11-DIHYDRO (1) BENZOXEPINO (3, 4-B) -PYRIDIN-5-OL USING TMEDA<br/>[FR] PROCÉDÉ DE PRÉPARATION DE 5-CYCLOPROPYL-5, 11-DIHYDRO(1)BENZOXÉPINO(3, 4-B)-PYRIDIN-5-OL À L'AIDE DE TMEDA
  申请人：MILLENNIUM PHARM INC

  公开号：WO2009073462A1

  公开（公告）日：2009-06-11

  An improved chemical synthesis for compounds having useful biological activity is disclosed, where the use of TMEDA or N,N,N',N'-tetramethyl-ethane-1,2-diamine gives improved yield.

  本发明揭示了一种改进的化学合成方法，用于合成具有有用生物活性的化合物，其中使用TMEDA或N，N，N'，N'-四甲基乙烷-1,2-二胺可提高产率。
• CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR
  申请人：Luly Jay R.

  公开号：US20090281081A1

  公开（公告）日：2009-11-12

  Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.

  本发明涉及新化合物以及一种治疗与异常白细胞招募和/或激活相关的疾病的方法。该方法包括向需要治疗的受体内给予一种有效量的化合物，该化合物表示为：或其生理上可接受的盐。