1-Piperidinecarboxylic acid, 2-(2-hydroxyethyl)-, 2-methylpropyl ester | 119515-25-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-Piperidinecarboxylic acid, 2-(2-hydroxyethyl)-, 2-methylpropyl ester
• 英文别名: 2-methylpropyl 2-(2-hydroxyethyl)piperidine-1-carboxylate
• CAS: 119515-25-2
• 化学式: C₁₂H₂₃NO₃
• mdl: MFCD12812007
• 分子量: 229.32
• InChiKey: GAJBLKYYDVECGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.916
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] PYRROLO [1, 2-A] PYRAZINE DERIVATIVES AS VASOPRESSIN VIB RECEPTOR ANTAGONISTS<br/>[FR] DÉRIVÉS DE PYRROLO [1, 2-A] PYRAZINE ANTAGONISTES DES RÉCEPTEURS V1B DE LA VASOPRESSINE
  申请人：GLAXO GROUP LTD

  公开号：WO2009130231A1

  公开（公告）日：2009-10-29

  The present invention relates to novel compounds of formula (I) or salts thereof; wherein R is -X-[CH2]nCR4R5-Y; or a group G; R1 is H or C1 -C4 alkyl; R2 is aryl, heteroaryl or C3-C7 cycloalkyl, which may be substituted with one or more: halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, - CN; R3 is -CH2-C(=O)-NH-R6; X is -CR7R8-, -O-, -NR9-, -S-; Y is-NR10R11 R4 is H or C1 -C4 alkyl; R5 is H or C1 -C4 alkyl; R6 is C1-C6 alkyl, C3-C6 cycloalkyl; C3-C6 cycloalkyl- (C1 -C2 alkyl); which may be substituted by one or more halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy; R7 is H or C1 -C4 alkyl; R8 is H or C1 -C4 alkyl; R9 is H or C1 -C4 alkyl; R10 is H or C1-C4 alkyl, or together with R11 forms a 4-8 saturated or unsaturated heterocycle ring which may comprise a further heteroatom selected from O, S and -NR12; such heterocycle may be substituted by one or more halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy; R11 is H or C1 -C4 alkyl; R12 is H, C1-C6 alkyl, C3-C7 cycloalkyl; C3-C6 cycloalkyl- (C1 -C2 alkyl); which may be substituted by one or more halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy; G is one of the groups selected from the list consisting of G1, G2, G3, G4, G5, G6, G7, G8, G9, G10, G11 and G12; R 13 is H or C1-C4 alkyl, or together with R14 forms a 4-8 saturated or unsaturated heterocycle ring which may comprise a further heteroatom selected from O, S and -NR24; such heterocycle may be substituted by one or more halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy; R14 R16 is H, C1-C6 alkyl, C3-C7 cycloalkyl; C3-C6 cycloalkyl- (C1 -C2 alkyl); which may be substituted by one or more halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy; R15, R 17 correspond to H or C1-C4 alkyl and may assume different meanings; R 18 is H or C1-C4 alkyl, or together with R17 forms a 4-8 saturated or unsaturated heterocycle ring which may comprise a further heteroatom selected from O, S and -NR25; such heterocycle may be substituted by one or more halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy; R19, R20, R21, R22, R23, R24, R25 is H, C1-C6 alkyl, C3-C7 cycloalkyl; C3-C6 cycloalkyl- (C1 -C2 alkyl); which may be substituted by one or more halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy; R26, R27, R28, R29 is H, C1-C6 alkyl, C3-C7 cycloalkyl; C3-C6 cycloalkyl- (C1 -C2 alkyl); which may be substituted by one or more halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy; I, I' correspond to 1 or 2 and may assume different meanings; m, m', m", m"', mιv, mv correspond to 0, 1 or 2 and may assume different meanings; n is 1, 2 or 3; q is 1, 2 or 3; p, p', p", p'" correspond to 0, 1, 2 or 3 and may assume different meanings; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as antagonists of V1b receptors, e.g. to treat depression and anxiety.

  本发明涉及以下式（I）的新化合物或其盐；其中R为-X-[CH2]nCR4R5-Y；或者为基团G；R1为H或C1-C4烷基；R2为芳基、杂环芳基或C3-C7环烷基，可以被一个或多个卤素、C1-C4烷基、C1-C4烷氧基、C1-C4卤代烷基、C1-C4卤代烷氧基取代；R3为-CH2-C（=O）-NH-R6；X为-CR7R8-、-O-、-NR9-、-S-；Y为-NR10R11；R4为H或C1-C4烷基；R5为H或C1-C4烷基；R6为C1-C6烷基、C3-C6环烷基；C3-C6环烷基-（C1-C2烷基）；可以被一个或多个卤素、C1-C4烷基、C1-C4烷氧基、C1-C4卤代烷基、C1-C4卤代烷氧基取代；R7为H或C1-C4烷基；R8为H或C1-C4烷基；R9为H或C1-C4烷基；R10为H或C1-C4烷基，或者与R11一起形成一个含有O、S和-NR12等进一步杂原子的4-8饱和或不饱和杂环环；该杂环可以被一个或多个卤素、C1-C4烷基、C1-C4烷氧基、C1-C4卤代烷基、C1-C4卤代烷氧基取代；R11为H或C1-C4烷基；R12为H、C1-C6烷基、C3-C7环烷基；C3-C6环烷基-（C1-C2烷基）；可以被一个或多个卤素、C1-C4烷基、C1-C4烷氧基、C1-C4卤代烷基、C1-C4卤代烷氧基取代；G为从G1、G2、G3、G4、G5、G6、G7、G8、G9、G10、G11和G12的列表中选择的一种基团；R13为H或C1-C4烷基，或者与R14一起形成一个含有O、S和-NR24等进一步杂原子的4-8饱和或不饱和杂环环；该杂环可以被一个或多个卤素、C1-C4烷基、C1-C4烷氧基、C1-C4卤代烷基、C1-C4卤代烷氧基取代；R14 R16为H、C1-C6烷基、C3-C7环烷基；C3-C6环烷基-（C1-C2烷基）；可以被一个或多个卤素、C1-C4烷基、C1-C4烷氧基、C1-C4卤代烷基、C1-C4卤代烷氧基取代；R15、R17对应于H或C1-C4烷基，可能具有不同的含义；R18为H或C1-C4烷基，或者与R17一起形成一个含有O、S和-NR25等进一步杂原子的4-8饱和或不饱和杂环环；该杂环可以被一个或多个卤素、C1-C4烷基、C1-C4烷氧基、C1-C4卤代烷基、C1-C4卤代烷氧基取代；R19、R20、R21、R22、R23、R24、R25为H、C1-C6烷基、C3-C7环烷基；C3-C6环烷基-（C1-C2烷基）；可以被一个或多个卤素、C1-C4烷基、C1-C4烷氧基、C1-C4卤代烷基、C1-C4卤代烷氧基取代；R26、R27、R28、R29为H、C1-C6烷基、C3-C7环烷基；C3-C6环烷基-（C1-C2烷基）；可以被一个或多个卤素、C1-C4烷基、C1-C4烷氧基、C1-C4卤代烷基、C1-C4卤代烷氧基取代；I、I'对应于1或2，可能具有不同的含义；m、m'、m"、m"'、mιv、mv对应于0、1或2，可能具有不同的含义；n为1、2或3；q为1、2或3；p、p'、p"、p"'对应于0、1、2或3，可能具有不同的含义；它们的制备方法、在这些方法中使用的中间体、含有它们的药物组合物以及它们作为V1b受体拮抗剂在治疗中的用途，例如用于治疗抑郁症和焦虑症。
• ALPHA-AMINO ACID DERIVATIVES FOR IMPROVING SOLUBILITY
  申请人：Rudolph Thomas

  公开号：US20110039924A1

  公开（公告）日：2011-02-17

  The invention relates to the use of α-amino acid derivatives for improving the solubility of poorly soluble substances in water or aqueous solutions and to mixtures and preferred preparations.

  这项发明涉及使用α-氨基酸衍生物来提高水或水溶液中难溶物质的溶解度，以及混合物和优选制剂。
• Novel Insect-Repellent Coumarin Derivatives, Syntheses, and Methods of Use
  申请人：Delaveau Jean

  公开号：US20120329832A1

  公开（公告）日：2012-12-27

  This invention relates to novel coumarin derivative, formulations comprising same, and to methods of making and using these compounds and formulations, which are useful as repellents against insects and/or pests. The compounds also prevent illness and disease caused by insect/pest-borne vectors, and provide safer, more effective alternatives to existing repellents.

  本发明涉及新型香豆素衍生物、包含该衍生物的配方，以及制备和使用这些化合物和配方的方法，这些化合物和配方可作为驱虫剂防止昆虫和/或害虫。这些化合物还可以预防因昆虫/害虫传播的疾病和疾病，并提供比现有驱虫剂更安全、更有效的替代品。
• [DE] CHROMON-KOMPLEXE<br/>[EN] CHROMONE COMPLEXES<br/>[FR] COMPLEXES DE CHROMONE
  申请人：MERCK PATENT GMBH

  公开号：WO2005097772A1

  公开（公告）日：2005-10-20

  Die Erfindung betrifft Komplexe bestimmter Chromon-Derivate, Zubereitungen, die solche Derivate enthalten, entsprechende Verfahren zur Herstellung der Chromon-Derivate bzw. von diese enthaltenden Zubereitungen und deren Verwendung, insbesondere zur Pflege, Konservierung oder Verbesserung des allgemeinen Zustandes der Haut oder Haare.

  这项发明涉及特定的色酮衍生物复合物，含有这些衍生物的制剂，制备色酮衍生物或含有这些衍生物的制剂的相应方法以及它们的用途，特别是用于皮肤或头发的护理、保养或改善整体状态。
• Chromone complexes
  申请人：Carola Christophe

  公开号：US20070191305A1

  公开（公告）日：2007-08-16

  The invention relates to complexes of certain chromone derivatives, to compositions which comprise such derivatives, to corresponding processes for the preparation of the chromone derivatives or of compositions comprising same, and to the use thereof, in particular for the care, maintenance or improvement of the general state of the skin or hair.

  该发明涉及某些咖啡因衍生物的络合物，以及包含这些衍生物的组合物，以及用于制备咖啡因衍生物或包含它们的组合物的相应过程，并且用途包括特别用于护理、维护或改善皮肤或头发的整体状态。