(3R)-3-methyl-1-(3-nitropyridin-2-yl) piperazine | 863713-30-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (3R)-3-methyl-1-(3-nitropyridin-2-yl) piperazine
• 英文别名: (3r)-3-Methyl-1-(3-nitropyridin-2-yl)piperazine
• CAS: 863713-30-8
• 化学式: C₁₀H₁₄N₄O₂
• 分子量: 222.247
• InChiKey: JRVIFHPFNSWJLO-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  74
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS<br/>[FR] COMPOSES DE TETRAZOLE ET LEUR UTILISATION COMME ANTAGONISTES DE RECEPTEURS DE GLUTAMATE METABOTROPIQUES
  申请人：ASTRAZENECA AB

  公开号：WO2005080356A1

  公开（公告）日：2005-09-01

  The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, R1, R2, m and p, are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds, and to the use of said compounds in therapy.

  本发明涉及公式I的新化合物，其中P、Q、X1、X2、X3、X4、R1、R2、m和p如公式I中所定义，或其盐、溶剂合物或溶剂化盐，其制备方法及用于制备所述化合物的新中间体，含有所述化合物的药物组合物，以及所述化合物在治疗中的使用。
• Cinnamamide compounds as metabotropic glutamate receptor antagonists
  申请人：Edwards Louise

  公开号：US20070049578A1

  公开（公告）日：2007-03-01

  The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where R 1 , R 2 , R 3 , A, X, and n are defined in the description. The invention also includes pharmaceutical compositions and uses of, and processes of making the compounds, as well as methods of medical treatment of mGluR 5 mediated disorders.

  该发明涉及公式I的化合物或其药用可接受的盐或溶剂化合物：其中R1、R2、R3、A、X和n在描述中有定义。该发明还包括药物组合物和使用以及制备这些化合物的方法，以及治疗mGluR 5介导的疾病的医疗方法。
• Tetrazole compounds and their use as metabotropic glutamate receptor antagonists
  申请人：Johansson Martin

  公开号：US20060004021A1

  公开（公告）日：2006-01-05

  The present invention relates to new compounds of formula I, wherein P, Q, X 1 , X 2 , X 3 , X 4 , R 1 , R 2 , m and p, are as defined as in formula I, or, salts, solvates or solvated salts thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.

  本发明涉及式I的新化合物，其中P、Q、X1、X2、X3、X4、R1、R2、m和p如式I中所定义，或其盐、溶剂合物或溶剂化盐，其制备过程以及用于制备它们的新中间体，含有所述化合物的制药组合物以及所述化合物在治疗中的使用。
• TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS
  申请人：AstraZeneca AB

  公开号：EP1716125A1

  公开（公告）日：2006-11-02
• US7691892B2
  申请人：——

  公开号：US7691892B2

  公开（公告）日：2010-04-06