1,3-O-bis(tert-butyldiphenylsilyl)-2,2-bis<<oxy>methyl>-1,3-propanediol | 214541-16-9

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 1,3-O-bis(tert-butyldiphenylsilyl)-2,2-bis<<oxy>methyl>-1,3-propanediol
• 英文别名: [2,2-bis[[tert-butyl(diphenyl)silyl]oxymethyl]-3-(3-hydroxypropylcarbamoyloxy)propyl] N-(3-hydroxypropyl)carbamate
• CAS: 214541-16-9
• 化学式: C₄₅H₆₂N₂O₈Si₂
• 分子量: 815.167
• InChiKey: NYQPFFJHRCGDIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.34
• 重原子数：
  57
• 可旋转键数：
  24
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  136
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  4,4'-双甲氧基三苯甲基氯 、 1,3-O-bis(tert-butyldiphenylsilyl)-2,2-bis<<oxy>methyl>-1,3-propanediol 以 吡啶 为溶剂， 反应 1.0h， 生成 {3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-propyl}-carbamic acid 2-{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propylcarbamoyloxymethyl}-3-(tert-butyl-diphenyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-propyl ester
  参考文献：
  名称：

  Nucleosides and Nucleotides. 182. Synthesis of Branched Oligodeoxynucleotides with Pentaerythritol at the Branch Point and Their Thermal Stabilization of Triplex Formation¹

  摘要：

  To find an oligodeoxynucleotide (ODN) with tripler stabilization capability, we designed and synthesized novel branched ODNs I and 2 with pentaerythritols at their branch points. Branched ODNs 1 and 2 were synthesized on a solid support using bis(phosphoramidite) 11. The stability of the triplexes, formed by branched ODNs 1 and 2 with (dA)(21) or (dT)(21) was studied by thermal denaturation. Branched ODN 1 formed a stable parallel T.AT-type tripler with (dA)(21) (T-m = 38.9 degrees C) in a buffer of 0.01 M sodium phosphate (pH 7.0) containing 0.5 M NaCl and 0.02 M MgCl2, while branched ODN 2 formed a stable antiparallel A.AT-type tripler with (dT)(21) (T-m = 44.2 degrees C) in the same buffer. The formation of these triplexes was also confirmed by circular dichroism (CD) measurements and a gel retardation assay.

  DOI：

  10.1021/jo981831e
• 作为产物：
  描述：

  叔丁基二苯基氯硅烷 在 咪唑 、 4-二甲氨基吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.17h， 生成 1,3-O-bis(tert-butyldiphenylsilyl)-2,2-bis<<oxy>methyl>-1,3-propanediol
  参考文献：
  名称：

  Nucleosides and Nucleotides. 182. Synthesis of Branched Oligodeoxynucleotides with Pentaerythritol at the Branch Point and Their Thermal Stabilization of Triplex Formation¹

  摘要：

  To find an oligodeoxynucleotide (ODN) with tripler stabilization capability, we designed and synthesized novel branched ODNs I and 2 with pentaerythritols at their branch points. Branched ODNs 1 and 2 were synthesized on a solid support using bis(phosphoramidite) 11. The stability of the triplexes, formed by branched ODNs 1 and 2 with (dA)(21) or (dT)(21) was studied by thermal denaturation. Branched ODN 1 formed a stable parallel T.AT-type tripler with (dA)(21) (T-m = 38.9 degrees C) in a buffer of 0.01 M sodium phosphate (pH 7.0) containing 0.5 M NaCl and 0.02 M MgCl2, while branched ODN 2 formed a stable antiparallel A.AT-type tripler with (dT)(21) (T-m = 44.2 degrees C) in the same buffer. The formation of these triplexes was also confirmed by circular dichroism (CD) measurements and a gel retardation assay.

  DOI：

  10.1021/jo981831e

文献信息

• Nucleosides and Nucleotides. 182. Synthesis of Branched Oligodeoxynucleotides with Pentaerythritol at the Branch Point and Their Thermal Stabilization of Triplex Formation¹
  作者：Yoshihito Ueno、Masako Takeba、Mai Mikawa、Akira Matsuda

  DOI：10.1021/jo981831e

  日期：1999.2.1

  To find an oligodeoxynucleotide (ODN) with tripler stabilization capability, we designed and synthesized novel branched ODNs I and 2 with pentaerythritols at their branch points. Branched ODNs 1 and 2 were synthesized on a solid support using bis(phosphoramidite) 11. The stability of the triplexes, formed by branched ODNs 1 and 2 with (dA)(21) or (dT)(21) was studied by thermal denaturation. Branched ODN 1 formed a stable parallel T.AT-type tripler with (dA)(21) (T-m = 38.9 degrees C) in a buffer of 0.01 M sodium phosphate (pH 7.0) containing 0.5 M NaCl and 0.02 M MgCl2, while branched ODN 2 formed a stable antiparallel A.AT-type tripler with (dT)(21) (T-m = 44.2 degrees C) in the same buffer. The formation of these triplexes was also confirmed by circular dichroism (CD) measurements and a gel retardation assay.