6-<4-<2-(2-methoxy-phenylthio)ethyl>-1-piperazinyl>-3(2H)pyridazinone | 145276-60-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 6-<4-<2-(2-methoxy-phenylthio)ethyl>-1-piperazinyl>-3(2H)pyridazinone
• 英文别名: 3-[4-[2-(2-methoxyphenyl)sulfanylethyl]piperazin-1-yl]-1H-pyridazin-6-one
• CAS: 145276-60-4
• 化学式: C₁₇H₂₂N₄O₂S
• 分子量: 346.453
• InChiKey: NIQULLVERIGJAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  82.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(2-methoxyphenylthio)ethylchloride 、 6-(哌嗪-1-基)吡嗪-3(2H)-酮 以 异戊醇 为溶剂， 反应 3.0h， 以40%的产率得到6-<4-<2-(2-methoxy-phenylthio)ethyl>-1-piperazinyl>-3(2H)pyridazinone
  参考文献：
  名称：

  Synthesis and pharmacological activity of some new pyridazinones

  摘要：

  The synthesis of a series of piperazinyl-pyridazinones is reported. The blocking activity of these compounds was determined on the pre- and postsynaptic alpha-adrenoreceptors of isolated rat vas deferens. For compounds 7, 17 and 18, the hypotensive activity was also evaluated.

  DOI：

  10.1016/0223-5234(92)90189-8

文献信息

• Synthesis and pharmacological activity of some new pyridazinones
  作者：S Corsano、G Strappaghetti、A Codagnone、R Scapicchi、G Marucci

  DOI：10.1016/0223-5234(92)90189-8

  日期：1992.8

  The synthesis of a series of piperazinyl-pyridazinones is reported. The blocking activity of these compounds was determined on the pre- and postsynaptic alpha-adrenoreceptors of isolated rat vas deferens. For compounds 7, 17 and 18, the hypotensive activity was also evaluated.