4-(4'-trifluoromethyl-biphenyl-2-carbonylamino)-1-methyl-pyrrole-2-carboxylic acid 、
4-(3-aza-spiro[5.5]undec-3-yl)-benzylamine 在
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、
三乙胺 作用下,
以
四氢呋喃 为溶剂,
以65%的产率得到N-[4-(3-Aza-spiro[5. 5]undec-3-yl)-phenylmethyl]-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-pyrrole-2-carboxylic acid amide