1-(1-Ethyl-1,6-dihydro-6-oxo-3-pyridazinyl)-4-piperidinyl 4-(1-methylethyl)-1-piperazinecarboxylate | 1542135-77-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(1-Ethyl-1,6-dihydro-6-oxo-3-pyridazinyl)-4-piperidinyl 4-(1-methylethyl)-1-piperazinecarboxylate
• 英文别名: [1-(1-ethyl-6-oxopyridazin-3-yl)piperidin-4-yl] 4-propan-2-ylpiperazine-1-carboxylate
• CAS: 1542135-77-2
• 化学式: C₁₉H₃₁N₅O₃
• 分子量: 377.5
• InChiKey: NQFIPWSBOZOBAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  68.7
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] CARBAMATE/UREA DERIVATIVES<br/>[FR] DÉRIVÉS DE CARBAMATE/URÉE
  申请人：NOVARTIS AG

  公开号：WO2014013469A1

  公开（公告）日：2014-01-23

  The invention relates to compound of the formula (I) or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.

  这项发明涉及公式（I）的化合物或其盐，其中取代基如规范中所定义；涉及其制备，涉及其作为药物的用途，以及包含它的药物。
• Carbamate/urea derivatives
  申请人：AUBERSON Yves

  公开号：US20140163036A1

  公开（公告）日：2014-06-12

  The invention relates to compound of the formula I or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.

  该发明涉及公式I的化合物或其盐，其中取代基如规范中所定义；涉及其制备，用作药物以及包含它的药物。
• [EN] NEW PROCESS FOR THE PREPARATION OF 2-CYCLOPENTYL-6-METHOXY-ISONICOTINIC ACID<br/>[FR] NOUVEAU PROCÉDÉ DE PRÉPARATION D'ACIDE 2-CYCLOPENTYL-6-MÉTHOXY-ISONICOTINIQUE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2013175397A1

  公开（公告）日：2013-11-28

  The present invention relates to new processes for the preparation of 2-cyclopentyl-6-methoxy-isonicotinic acid, which is a useful intermediate for the synthesis of pyridine-4-yl derivatives as immunomodulating agent. Moreover, the present invention also relates to new intermediates used in those processes.

  本发明涉及一种制备2-环戊基-6-甲氧基吡啶-4-基甲酸的新工艺，该化合物是合成吡啶-4-基衍生物作为免疫调节剂的有用中间体。此外，本发明还涉及用于这些工艺的新中间体。
• NEW PROCESS FOR THE PREPARATION OF 2-CYCLOPENTYL-6-METHOXY-ISONICOTINIC ACID
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：US20150133669A1

  公开（公告）日：2015-05-14

  The present invention relates to new processes for the preparation of 2-cyclopentyl-6-methoxy-isonicotinic acid, which is a useful intermediate for the synthesis of pyridine-4-yl derivatives as immunomodulating agent. Moreover, the present invention also relates to new intermediates used in those processes.

  本发明涉及制备2-环戊基-6-甲氧基异烟酸的新工艺，该化合物是合成吡啶-4-基衍生物免疫调节剂的有用中间体。此外，本发明还涉及在这些工艺中使用的新中间体。
• CARBAMATE/UREA DERIVATIVES
  申请人：AUBERSON Yves

  公开号：US20150218127A1

  公开（公告）日：2015-08-06

  The invention relates to compound of the formula I or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.

  本发明涉及式I的化合物或其盐，其中取代基如规范中所定义；其制备方法；其作为药物的用途及包含它的药物。