5-Fluoro-3-piperazin-1-yl-1H-indazole | 921224-96-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-Fluoro-3-piperazin-1-yl-1H-indazole
• 英文别名: 5-Fluoro-3-(piperazin-1-yl)-1H-indazole；5-fluoro-3-piperazin-1-yl-1H-indazole
• CAS: 921224-96-6
• 化学式: C₁₁H₁₃FN₄
• 分子量: 220.249
• InChiKey: HQFMSMNZKRJZNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  44
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-Fluoro-3-piperazin-1-yl-1H-indazole 、 氯甲酸苄酯 在 lanthanum(III) nitrate 作用下， 反应 0.17h， 以96%的产率得到4-(5-Fluoro-1H-indazol-3-yl)-piperazine-1-carboxylic acid benzyl ester
  参考文献：
  名称：

  A mild and efficient chemoselective protection of amines as N-benzyloxycarbonyl derivatives in the presence of La(NO3)3·6H2O under solvent-free conditions

  摘要：

  A facile and versatile method for the chemoselective N-benzyloxycarbonylation of amines has been developed by treatment with benzyloxycarbonyl chloride (Cbz-Cl) in the presence of lanthanum(III) nitrate hexahydrate under solvent-free conditions. The method is general for the preparation of N-Cbz derivatives of aliphatic (acyclic and cyclic) and aromatic amines. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.11.015

文献信息

• A mild and efficient chemoselective protection of amines as N-benzyloxycarbonyl derivatives in the presence of La(NO3)3·6H2O under solvent-free conditions
  作者：K. Chinni Mahesh、M. Narasimhulu、T. Srikanth Reddy、N. Suryakiran、Y. Venkateswarlu

  DOI：10.1016/j.tetlet.2006.11.015

  日期：2007.1

  A facile and versatile method for the chemoselective N-benzyloxycarbonylation of amines has been developed by treatment with benzyloxycarbonyl chloride (Cbz-Cl) in the presence of lanthanum(III) nitrate hexahydrate under solvent-free conditions. The method is general for the preparation of N-Cbz derivatives of aliphatic (acyclic and cyclic) and aromatic amines. (c) 2006 Elsevier Ltd. All rights reserved.