3-叔丁氧羰基氨基-1-哌啶甲酸叔丁酯 | 1217710-80-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 3-叔丁氧羰基氨基-1-哌啶甲酸叔丁酯
• 中文别名: 3-((叔丁氧基羰基)氨基)哌啶-1-羧酸叔丁酯
• 英文名称: tert-butyl 3-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate
• 英文别名: tert-butyl 3-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-1-carboxylate
• CAS: 1217710-80-9
• 化学式: C₁₅H₂₈N₂O₄
• mdl: MFCD16496415
• 分子量: 300.398
• InChiKey: IPDHHWCHJZHKMH-UHFFFAOYSA-N

物化性质

• 沸点：
  397.5±31.0 °C(Predicted)
• 密度：
  1.07

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.866
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2933399090
• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302

反应信息

• 作为产物：
  描述：

  在 caesium carbonate 作用下， 以 乙腈 为溶剂， 反应 5.0h， 以61%的产率得到3-叔丁氧羰基氨基-1-哌啶甲酸叔丁酯
  参考文献：
  名称：

  Base-Mediated Intramolecular Decarboxylative Synthesis of Alkylamines from Alkanoyloxycarbamates

  摘要：

  A general and effective method for the synthesis of alkylamine via intramolecular decarboxylation of alkanoyloxycarbamates is described. The alkanoyloxycarbamates are readily prepared with alkyl carboxylic acids and hydroxylamine. The reaction shows a broad range of substrates (primary and secondary alkyl) with functional tolerance, and the corresponding products were obtained in good yields under mild conditions.

  DOI：

  10.1021/acs.joc.8b00970

文献信息

• US9273028B2
  申请人：——

  公开号：US9273028B2

  公开（公告）日：2016-03-01
• Base-Mediated Intramolecular Decarboxylative Synthesis of Alkylamines from Alkanoyloxycarbamates
  作者：Peihe Li、Nuannuan Ma、Zheng Wang、Qipu Dai、Changwen Hu

  DOI：10.1021/acs.joc.8b00970

  日期：2018.8.3

  A general and effective method for the synthesis of alkylamine via intramolecular decarboxylation of alkanoyloxycarbamates is described. The alkanoyloxycarbamates are readily prepared with alkyl carboxylic acids and hydroxylamine. The reaction shows a broad range of substrates (primary and secondary alkyl) with functional tolerance, and the corresponding products were obtained in good yields under mild conditions.