2,5-Dioxopyrrolidin-1-yl 3-(2-(2-(5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethoxy)ethoxy)propanoate | 365441-71-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 英文名称: 2,5-Dioxopyrrolidin-1-yl 3-(2-(2-(5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethoxy)ethoxy)propanoate
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanoylamino]ethoxy]ethoxy]propanoate
• CAS: 365441-71-0
• 化学式: C₂₁H₃₂N₄O₈S
• 分子量: 500.6
• InChiKey: UCJSJBIJPAZUGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  34
• 可旋转键数：
  16
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  178
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Heterotandem bicyclic peptide complex
  申请人：BicycleTx Limited

  公开号：US11312749B2

  公开（公告）日：2022-04-26

  The present invention relates to a heterotandem bicyclic peptide complex which comprises a first peptide ligand, which binds to EphA2, conjugated via a linker to two second peptide ligands, which bind to CD137. The invention also relates to the use of said heterotandem bicyclic peptide complex in preventing, suppressing or treating cancer.

  本发明涉及一种异链双环肽复合物，它包括与 EphA2 结合的第一肽配体，该配体通过连接体与与 CD137 结合的两个第二肽配体连接。本发明还涉及所述杂环双肽复合物在预防、抑制或治疗癌症中的用途。
• HETEROTANDEM BICYCLIC PEPTIDE COMPLEX
  申请人：BicycleTx Limited

  公开号：US20210069287A1

  公开（公告）日：2021-03-11

  The present invention relates to a heterotandem bicyclic peptide complex which comprises a first peptide ligand, which binds to EphA2, conjugated via a linker to two second peptide ligands, which bind to CD137. The invention also relates to the use of said heterotandem bicyclic peptide complex in preventing, suppressing or treating cancer.