N-(1-(3,5-diethoxy-4-(1H-imidazol-1-yl)benzyl)piperidin-4-yl)-5-methylnicotinamide | 916338-00-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(1-(3,5-diethoxy-4-(1H-imidazol-1-yl)benzyl)piperidin-4-yl)-5-methylnicotinamide
• 英文别名: N-[1-[(3,5-diethoxy-4-imidazol-1-ylphenyl)methyl]piperidin-4-yl]-5-methylpyridine-3-carboxamide
• CAS: 916338-00-6
• 化学式: C₂₆H₃₃N₅O₃
• 分子量: 463.58
• InChiKey: YTYBDUVKLIFXAG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  81.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5-methyl-N-(piperidin-4-yl)-nicotinamide 、 3,5-diethoxy-4-(imidazol-1-yl)-benzaldehyde 在 titanium(IV) isopropylate 、 sodium cyanoborohydride 作用下， 以 异丙醇 为溶剂， 反应 14.0h， 生成 N-(1-(3,5-diethoxy-4-(1H-imidazol-1-yl)benzyl)piperidin-4-yl)-5-methylnicotinamide
  参考文献：
  名称：

  Piperidinyl-nicotinamides as potent and selective somatostatin receptor subtype 5 antagonists

  摘要：

  Nicotinamides of benzyl-substituted 4-aminopiperidines and their seven-membered analogs of generic structure 2 and 20 have been discovered as potent and selective SST5 antagonists. The activity (K-i) ranges from 2.4 to 436 nM. Most compounds exhibit decent physicochemical properties and follow a clear SAR pattern. Interestingly enough, the receptor is strongly enantiodiscriminating and binds in the amino-azepaneseries only the (R)-enantiomer. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.06.026

文献信息

• Amide derivatives as somatostatin receptor 5 antagonists
  申请人：Binggeli Alfred

  公开号：US20060276508A1

  公开（公告）日：2006-12-07

  This invention is concerned with compounds of the formula wherein R 1 to R 5 , R 5′ and A are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.

  这项发明涉及以下式中的化合物，其中R1至R5、R5'和A如描述和索赔中所定义，并且其药学上可接受的盐。该发明还涉及含有这种化合物的药物组合物，以及用于治疗和/或预防与调节SST受体亚型5相关的疾病的方法。
• PIPERIDIN-4-YL-AMIDE DERIVATIVES AND THEIR USE AS SST RECEPTOR SUBTYPE 5 ANTAGONISTS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP1893603B1

  公开（公告）日：2009-10-14
• US7772253B2
  申请人：——

  公开号：US7772253B2

  公开（公告）日：2010-08-10