2-[5-[4-[[4-(1-Methylethoxy)phenyl]sulfonyl]-1-piperazinyl]-2-(5-methyl-1,3,4-thiadiazol-2-yl)phenoxy]acetic acid | 932372-02-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[5-[4-[[4-(1-Methylethoxy)phenyl]sulfonyl]-1-piperazinyl]-2-(5-methyl-1,3,4-thiadiazol-2-yl)phenoxy]acetic acid
• 英文别名: 2-[2-(5-methyl-1,3,4-thiadiazol-2-yl)-5-[4-(4-propan-2-yloxyphenyl)sulfonylpiperazin-1-yl]phenoxy]acetic acid
• CAS: 932372-02-6
• 化学式: C₂₄H₂₈N₄O₆S₂
• 分子量: 532.642
• InChiKey: FXIVHOSCWGHDMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  159
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• SULFONAMIDE DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY
  申请人：SHIONOGI & CO., LTD.

  公开号：US20150158833A1

  公开（公告）日：2015-06-11

  The present invention provides an sulfonamide derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. A compound of the general formula (II): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the ring C is an aromatic carbocyclic ring etc.; R1 is carboxy etc.; R2 is independently a halogen atom etc.; R3 is optionally substituted alkyloxy etc.; R4 is independently a halogen atom etc.; R5 is independently optionally substituted alkyl etc.; M is sulfonyl etc.; Y is a single bond etc.; L1 is a single bond etc.; L2 is a single bond etc.; k is 0, 1, 2, 3 or 4; n is 0, 1 or 2; and q is 0, 1, 2 or 3; provided that a) k is not 0 when the ring B is a 6-membered nitrogen-containing heterocyclic ring containing one or two nitrogen atom(s) and the ring C is a benzene ring, etc.; a pharmaceutically acceptable salt or a hydrate thereof.
• US9440938B2
  申请人：——

  公开号：US9440938B2

  公开（公告）日：2016-09-13