Guanosine 5a(2)-(trihydrogen diphosphate), Pa(2)-[[(2R,3R,4R,5S)-3,4-dihydroxy-5-methyl-2-pyrrolidinyl]methyl] ester | 364606-66-6

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: Guanosine 5a(2)-(trihydrogen diphosphate), Pa(2)-[[(2R,3R,4R,5S)-3,4-dihydroxy-5-methyl-2-pyrrolidinyl]methyl] ester
• 英文别名: [[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3R,4R,5S)-3,4-dihydroxy-5-methylpyrrolidin-2-yl]methyl hydrogen phosphate
• CAS: 364606-66-6
• 化学式: C₁₆H₂₆N₆O₁₃P₂
• 分子量: 572.362
• InChiKey: QYHZMOGBCRKXMU-NMTIVPGBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.5
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  302
• 氢给体数：
  7
• 氢受体数：
  14

反应信息

• 作为产物：
  描述：

  guanosine 5'-phosphoromorpholidate 、 phosphoric acid mono-(3R,4R-dihydroxy-5S-methyl-pyrrolidin-2R-ylmethyl) ester 在 四氮唑 作用下， 以40%的产率得到Guanosine 5a(2)-(trihydrogen diphosphate), Pa(2)-[[(2R,3R,4R,5S)-3,4-dihydroxy-5-methyl-2-pyrrolidinyl]methyl] ester
  参考文献：
  名称：

  Inhibition of fucosyltransferase V by a GDP–Azasugar

  摘要：

  A GDP-azasugar conjugate was synthesized starting from an enzymatically obtained phosphorylated azasugar. It inhibits human fucosyltransferase V at micromolar concentrations, which is discussed in terms of transition state analogy. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00282-7