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3-溴-2-甲基苯酰肼 | 108708-22-1

中文名称
3-溴-2-甲基苯酰肼
中文别名
——
英文名称
(2R,3S,4R,5R)-2,3,4,5-tetrahydroxy-6-[(4-nitro-2,1,3-benzoxadiazol-7-yl)amino]hexanal
英文别名
——
3-溴-2-甲基苯酰肼化学式
CAS
108708-22-1
化学式
C12H14N4O8
mdl
——
分子量
342.26
InChiKey
DEPMSUUWSGUYKQ-IWXIMVSXSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    729.5±70.0 °C(Predicted)
  • 密度:
    1.750±0.06 g/cm3(Predicted)
  • 溶解度:
    DMF:10mg/mL; DMSO:10mg/mL;乙醇:微溶; PBS(pH 7.2):10 mg/mL

计算性质

  • 辛醇/水分配系数(LogP):
    -1.4
  • 重原子数:
    24
  • 可旋转键数:
    7
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.42
  • 拓扑面积:
    195
  • 氢给体数:
    5
  • 氢受体数:
    11

文献信息

  • Methods for cancer imaging
    申请人:Threshold Pharmaceuticals, Inc.
    公开号:US20030152518A1
    公开(公告)日:2003-08-14
    Methods are provided for cancer and pre-cancer detection by increased uptake of fluorophore glucose or deoxyglucose conjugates in cancerous and pre-cancerous cells relative to normal cells.
    本方法提供了一种通过相对于正常细胞,癌细胞和癌前细胞中荧光素葡萄糖或去氧葡萄糖共轭物的摄取量增加来进行癌症和癌前病变检测的方法。
  • METHOD FOR EVALUATING SPECIFIC INCORPORATION OF D-GLUCOSE INTO CELLS
    申请人:Yamada Katsuya
    公开号:US20110189708A1
    公开(公告)日:2011-08-04
    An object of the present invention is to provide a method for accurately evaluating the specific incorporation of D-glucose into cells. The present invention as a means for achieving the object is characterized by comprising contacting a D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells and an L-glucose derivative that has a fluorescent chromophore in the molecule with different cells in the same cell strain to be evaluated, respectively, comparing the fluorescence emitted by the D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells with the fluorescence emitted by the L-glucose derivative that has a fluorescent chromophore in the molecule, and evaluating the specific incorporation of D-glucose into cells relative to L-glucose by taking the difference between the two kinds of fluorescence intensities.
    本发明的目的是提供一种准确评估D-葡萄糖进入细胞的特定结合的方法。本发明的手段是通过将具有荧光色团的D-葡萄糖衍生物和具有荧光色团的L-葡萄糖衍生物与同一细胞系的不同细胞接触,分别比较具有荧光色团的D-葡萄糖衍生物和特定结合到细胞中的荧光强度与具有荧光色团的L-葡萄糖衍生物的荧光强度,并通过两种荧光强度的差异来评估D-葡萄糖相对于L-葡萄糖的特定结合到细胞中的情况。
  • L-glucose derivatives having fluorescent chromophore
    申请人:HIROSAKI UNIVERSITY
    公开号:US20150212094A1
    公开(公告)日:2015-07-30
    An object of the present invention is to provide a method for accurately evaluating the specific incorporation of D-glucose into cells. The present invention as a means for achieving the object is characterized by comprising contacting a D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells and an L-glucose derivative that has a fluorescent chromophore in the molecule with different cells in the same cell strain to be evaluated, respectively, comparing the fluorescence emitted by the D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells with the fluorescence emitted by the L-glucose derivative that has a fluorescent chromophore in the molecule, and evaluating the specific incorporation of D-glucose into cells relative to L-glucose by taking the difference between the two kinds of fluorescence intensities.
    本发明的目的是提供一种准确评估D-葡萄糖特异性进入细胞的方法。本发明的手段是通过将具有荧光色团的D-葡萄糖衍生物与分别具有荧光色团的L-葡萄糖衍生物接触同一细胞系的不同细胞,比较D-葡萄糖衍生物和L-葡萄糖衍生物发出的荧光,通过两种荧光强度之间的差异来评估D-葡萄糖相对于L-葡萄糖特异性地进入细胞。
  • METHOD FOR SCREENING DIABETES TREATING AGENT
    申请人:Gwangju Institute of Science and Technology
    公开号:EP2600147A2
    公开(公告)日:2013-06-05
    The present invention provides a method for screening a diabetes treating agent comprising the following steps: (a) preparing cells inside a culture medium; (b) treating the culture medium with a test substance; (c) treating the result of step (b) with a glucose derivative which is not metabolized; and (d) measuring the glucose derivative which has flowed into the cells, wherein the test substance is determined to be a diabetes treating agent if the test substance accelerates uptake of the glucose derivative in the cells. Therefore, the described pharmaceutical composition, including a triazin-based compound as an active ingredient, can be useful for application in preventing or treating diabetes.
    本发明提供了一种筛选糖尿病治疗药物的方法,包括以下步骤:(a) 在培养基内制备细胞;(b) 用试验物质处理培养基;(c) 用未代谢的葡萄糖衍生物处理步骤(b)的结果;(d) 测量流入细胞的葡萄糖衍生物,其中,如果试验物质加速了细胞对葡萄糖衍生物的吸收,则确定该试验物质为糖尿病治疗剂。因此,所述药物组合物(包括作为活性成分的三嗪类化合物)可用于预防或治疗糖尿病。
  • COMPOSITION FOR IMPROVING BLOOD SUGAR METABOLISM
    申请人:Sunstar Inc.
    公开号:EP3042661A1
    公开(公告)日:2016-07-13
    An object of the present invention is to provide a composition for improving blood sugar metabolism, the composition improving and/or enhancing sugar metabolism function in skeletal muscle. The present invention provides a composition for improving blood sugar metabolism, the composition comprising a persimmon leaf extract obtained by a process comprising extracting persimmon leaves with a 40-60% ethyl alcohol- water mixture.
    本发明的目的是提供一种用于改善血糖代谢的组合物,该组合物可改善和/或增强骨骼肌的糖代谢功能。本发明提供了一种用于改善血糖代谢的组合物,该组合物包含一种柿叶提取物,该柿叶提取物的工艺包括用 40-60% 的乙醇-水混合物提取柿叶。
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