5-amino-2-pentyl-7-N-piperazino-oxazolo[5,4-d]pyrimidine | 1245319-16-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-amino-2-pentyl-7-N-piperazino-oxazolo[5,4-d]pyrimidine
• 英文别名: 2-Pentyl-7-piperazin-1-yl-[1,3]oxazolo[5,4-d]pyrimidin-5-amine
• CAS: 1245319-16-7
• 化学式: C₁₄H₂₂N₆O
• 分子量: 290.368
• InChiKey: YUKRSEYEWNHDMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES
  申请人：Katholieke Universiteit Leuven, K.U. Leuven R&D

  公开号：EP2616077A1

  公开（公告）日：2013-07-24
• [EN] ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES<br/>[FR] ACTIVITÉ ANTICANCÉREUSE DE NOUVEAUX HÉTÉROCYCLES BICYCLIQUES
  申请人：UNIV LEUVEN KATH

  公开号：WO2012035423A1

  公开（公告）日：2012-03-22

  The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, Formulas (I), (II), (III) and (IV) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1 or as described in detail in the description of the invention, and to the use of said compounds to treat or prevent proliferative disorders and their use to manufacture a medicine to treat or prevent proliferative disorders, particularly cancer such as leukemia. The present invention also relates to pharmaceutical compositions of said compounds and the use of said pharmaceutical compositions to treat or prevent proliferative disorders. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of proliferative disorders and pathologic conditions such as, but not limited to, cancer such as leukemia.