Succinic acid mono-[2-(2-{2-[2-(2-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-ethoxy)-ethyldisulfanyl]-ethoxy}-ethoxy)-ethyl] ester | 136055-03-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: Succinic acid mono-[2-(2-{2-[2-(2-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-ethoxy)-ethyldisulfanyl]-ethoxy}-ethoxy)-ethyl] ester
• CAS: 136055-03-3
• 化学式: C₃₇H₄₈O₁₁S₂
• 分子量: 732.914
• InChiKey: IWKBHGAUCXOQRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.87
• 重原子数：
  50.0
• 可旋转键数：
  28.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  128.21
• 氢给体数：
  1.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  对硝基苯酚 、 Succinic acid mono-[2-(2-{2-[2-(2-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-ethoxy)-ethyldisulfanyl]-ethoxy}-ethoxy)-ethyl] ester 在 N,N'-二环己基碳二亚胺 作用下， 生成 Succinic acid 2-(2-{2-[2-(2-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-ethoxy)-ethyldisulfanyl]-ethoxy}-ethoxy)-ethyl ester 4-nitro-phenyl ester
  参考文献：
  名称：

  Solid phase synthesis of 5',3'-bifunctional oligodeoxyribonucleotides bearing a masked thiol group at the 3'-end

  摘要：

  Immobilization of the ''disulfide arm'' 8 on a solid support via a succinyl linkage allows the automated synthesis of modified oligonucleotides bearing a disulfide or a thiol function at the 3'-end and other modifications at the 5'-end.

  DOI：

  10.1016/0040-4039(91)80686-z
• 作为产物：
  描述：

  3,6-二噁-8-疏基辛烷-1-醇 在 吡啶 、 4-二甲氨基吡啶 、 ammonium hydroxide 、 氧气 作用下， 反应 50.0h， 生成 Succinic acid mono-[2-(2-{2-[2-(2-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-ethoxy)-ethyldisulfanyl]-ethoxy}-ethoxy)-ethyl] ester
  参考文献：
  名称：

  Solid-phase preparation of 5′,3′-heterobifunctional oligodeoxyribonucleotides using modified solid supports

  摘要：

  The solid-phase preparation of oligodeoxyribonucleotides attached to intercalator or reactive groups through their 5'- and (or) 3'-ends is reported. These syntheses implicate the introduction of suitable masked functional groups at the 5'-end of the oligonucleotide by the intermediate of their phosphoramidite derivatives or at the 3'-end of the oligonucleotide using modified solid supports. After full deblocking, the functional groups (phosphate, thiophosphate, primary amine or thiol) can be reacted with the suitable reactive group involved in the chosen ligand. These methods allow the preparation of heterobifunctional derivatized oligodeoxyribonucleotides.

  DOI：

  10.1016/s0040-4020(01)90786-0