N-(2-(1-piperazinyl)-5-pyrimidinyl)-2',3',5',6'-tetrahydro-spiro[chromeno[3,4-d]pyrimidine-5,4'-pyrane]-3-amine | 1190961-41-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-(2-(1-piperazinyl)-5-pyrimidinyl)-2',3',5',6'-tetrahydro-spiro[chromeno[3,4-d]pyrimidine-5,4'-pyrane]-3-amine
• 英文别名: N-(2-piperazin-1-ylpyrimidin-5-yl)spiro[chromeno[3,4-d]pyrimidine-5,4'-oxane]-3-amine
• CAS: 1190961-41-1
• 化学式: C₂₃H₂₅N₇O₂
• 分子量: 431.497
• InChiKey: RVUSMBDDJZRKSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  97.3
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• [EN] GEM-DISUBSTITUTED AND SPIROCYCLIC AMINO PYRIDINES/PYRIMIDINES AS CELL CYCLE INHIBITORS<br/>[FR] PYRIDINES/PYRIMIDINES AMINO SPIROCYCLIQUES ET DISUBSTITUÉES PAR GEM EN TANT QU'INHIBITEURS DE CYCLE CELLULAIRE
  申请人：AMGEN INC

  公开号：WO2009126584A1

  公开（公告）日：2009-10-15

  Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are gem-disubstituted or spirocyclic pyridine, pyrimidine and triazine derivatives.

  提供了一些化合物、药物组合物和方法，这些化合物、药物组合物和方法可用于治疗CDK4介导的疾病，如癌症。所述化合物是 gem-二取代或螺环的吡啶、嘧啶和三嗪衍生物。
• [EN] HETEROCYCLES AS PROTEIN KINASE INHIBITORS<br/>[FR] HÉTÉROCYCLES EN TANT QU'INHIBITEURS DE PROTÉINE KINASE
  申请人：AMGEN INC

  公开号：WO2009143477A1

  公开（公告）日：2009-11-26

  Selected fused imidazole or triazole derivatives are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的融合咪唑或三唑衍生物对于预防和治疗疾病，如HGF介导的疾病，具有有效性。该发明涵盖了新颖的化合物、类似物、前药和其药用可接受盐，以及用于预防和治疗涉及癌症等疾病和其他疾病或病况的药物组合物和方法。该发明还涉及制备此类化合物的工艺以及在此类工艺中有用的中间体。
• Gem-Disubstituted and Spirocyclic Amino Pyridines/Pyrimidines as Cell Cycle Inhibitors
  申请人：Connors Richard V.

  公开号：US20110097305A1

  公开（公告）日：2011-04-28

  Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-me-dialed disorders, such as cancer. The subject compounds arc gem-disubstituted or spimcyclic pyridine, pyrimidine and triazine derivatives.

  本文提供了化合物、药物组合物和方法，用于治疗CDK4介导的疾病，如癌症。所述化合物为gem-二取代或螺环式吡啶、嘧啶和三嗪衍生物。
• COMBINATIONS FOR THE TREATMENT OF CANCER COMPRISING ANTI-EGFR ANTIBODY AND VEGFR INHIBITORS
  申请人：Amgen, Inc

  公开号：EP1915151A2

  公开（公告）日：2008-04-30
• FUSED HETEROCYCLIC DERIVATIVES USEFUL AS INHIBITORS OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR
  申请人：Amgen Inc.

  公开号：EP2081931A2

  公开（公告）日：2009-07-29