[4-(2-Chloro-4-nitrophenyl)piperazin-1-yl]-[3-(2-methoxynaphthalen-1-yl)-5-methyl-1,2-oxazol-4-yl]methanone | 1370419-98-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: [4-(2-Chloro-4-nitrophenyl)piperazin-1-yl]-[3-(2-methoxynaphthalen-1-yl)-5-methyl-1,2-oxazol-4-yl]methanone
• CAS: 1370419-98-9
• 化学式: C₂₆H₂₃ClN₄O₅
• 分子量: 506.945
• InChiKey: KTCRBFBZSWVNKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  36
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• NOVEL PIPERAZINE ANALOGS WITH SUBSTITUTED HETEROARYL GROUPS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS
  申请人：Bristol-Myers Squibb Company

  公开号：EP2621920B1

  公开（公告）日：2016-01-27
• [EN] NOVEL PIPERAZINE ANALOGS WITH SUBSTITUTED HETEROARYL GROUPS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS<br/>[FR] NOUVEAUX ANALOGUES DE LA PIPÉRAZINE COMPORTANT DES GROUPES HÉTÉROARYLE SUBSTITUÉS UTILISÉS COMME ANTIVIRAUX À LARGE SPECTRE PROTÉGEANT DE LA GRIPPE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2012044531A1

  公开（公告）日：2012-04-05

  A compound of the following Formula (I) is set forth, including pharmaceutically acceptable salts thereof: wherein Het is a 5 or 6-membered heterocycle with -N, -O, or -S adjacent to the -Ar substituent or adjacent to the point of attachment for the -Ar substituent; Ar is aryl or heteroaryl; R is -CH3, -CH2F, -CHF2 or -CH=CH2; V is -H, -CH3 or =0; W is -NO2, -CI, -Br, -CH2OH, or -CN; X is -CI, -Br, -F, -CH3, -OCH3, or -CN; Y is -CH or -N; and Z is -CH or -N. This compound is useful in compositions for the prevention and treatment of influenza virus.