[[(2R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: [[(2R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate
• 化学式: C₂₁H₃₆N₇O₁₆P₃S
• 分子量: 767.5
• InChiKey: RGJOEKWQDUBAIZ-HDYAHSQZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.8
• 重原子数：
  48
• 可旋转键数：
  18
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  348
• 氢给体数：
  10
• 氢受体数：
  21

文献信息

• PRODUCTION OF N-ACYLATED SULPHUR-CONTAINING AMINO ACIDS WITH MICROORGANISMS HAVING ENHANCED N-ACYLTRANSFERASE ENZYMATIC ACTIVITY
  申请人：FIGGE RAINER

  公开号：US20100047880A1

  公开（公告）日：2010-02-25

  The present invention claims an isolated polypeptide having L-amino-acid-N-acyl transferase enzymatic activity and a modified microorganism in which this enzyme is overexpressed. Substrates of said enzyme include mainly methionine and their derivatives or analogs. Overexpression in sulphur-containing amino acid producing microorganisms permits the production of large amounts of N-acylated sulphur-containing amino acids. The isolation of the N-acylated sulphur-containing amino acids from the fermentation medium is also claimed.

  本发明声明了一种具有L-氨基酸-N-酰基转移酶活性的分离多肽和一种改良的微生物，其中这种酶被过度表达。该酶的底物主要包括蛋氨酸及其衍生物或类似物。在含硫氨基酸生产微生物中过度表达可以生产大量的N-酰化含硫氨基酸。同时本发明还声明了从发酵介质中分离出N-酰化含硫氨基酸的方法。