2-[4-(4-hydroxyphenyl)piperazin-1-yl]-N,N-dimethyl-2-phenylacetamide | 1214022-77-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[4-(4-hydroxyphenyl)piperazin-1-yl]-N,N-dimethyl-2-phenylacetamide
• CAS: 1214022-77-1
• 化学式: C₂₀H₂₅N₃O₂
• mdl: MFCD11339944
• 分子量: 339.4
• InChiKey: JLBLWKBIMHNYQW-UHFFFAOYSA-N

物化性质

• 沸点：
  530.6±50.0 °C(Predicted)
• 密度：
  1.194±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  47
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Small molecule drugs and related methods for treatment of diseases related to Aβ42 oligomer formation
  申请人：ACELOT, INC.

  公开号：US10703711B2

  公开（公告）日：2020-07-07

  The present invention provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of Aβ42 oligomers in a subject. It further provides a method of reducing formation of or disrupting Aβ42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.

  本发明提供了用于治疗和预防与受试者体内Aβ42低聚物的形成有关的疾病的小分子药物和药物组合物。本发明进一步提供了一种减少受试者体内 Aβ42 寡聚体的形成或破坏 Aβ42 寡聚体的方法，该方法包括向有需要的受试者施用治疗有效量的药物组合物的步骤。
• SMALL MOLECULE DRUGS AND RELATED METHODS FOR TREATMENT OF DISEASES RELATED TO A 42 OLIGOMER FORMATION
  申请人：Acelot, Inc.

  公开号：EP3706727A1

  公开（公告）日：2020-09-16
• SMALL MOLECULE DRUGS AND RELATED METHODS FOR TREATMENT OF DISEASES RELATED TO TDP-43, ALPHA-SYNUCLEIN, HUNTINGTIN'S PROTEIN AND TAU PROTEIN OLIGOMER FORMATION
  申请人：Acelot, Inc.

  公开号：EP3993781A1

  公开（公告）日：2022-05-11
• Small molecule drugs and related methods for treatment of diseases related to abeta42 oligomer formation
  申请人：ACELOT, INC.

  公开号：US20190210959A1

  公开（公告）日：2019-07-11

  The present invention provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of Aβ42 oligomers in a subject. It further provides a method of reducing formation of or disrupting Aβ42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.
• SMALL MOLECULE DRUGS AND RELATED METHODS FOR TREATMENT OF DISEASES RELATED TO ABETA42 OLIGOMER FORMATION
  申请人：ACELOT, INC.

  公开号：US20200223788A1

  公开（公告）日：2020-07-16

  The present invention provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of Aβ42 oligomers in a subject. It further provides a method of reducing formation of or disrupting Aβ42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.