potassium;2,6-dimethylpiperidine-1-carbodithioate | 119304-11-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: potassium;2,6-dimethylpiperidine-1-carbodithioate
• CAS: 119304-11-9
• 化学式: C₈H₁₄NS₂*K
• 分子量: 227.436
• InChiKey: YBSAXBZVHRMZSX-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.91
• 重原子数：
  12.0
• 可旋转键数：
  0.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  3.24
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  potassium;2,6-dimethylpiperidine-1-carbodithioate 在 盐酸 、 sodium nitrite 作用下， 以 甲醇 、 水 为溶剂， 生成 2,6-dimethylpiperidine-1-carbothioic dithioperoxyanhydride
  参考文献：
  名称：

  Bis(dialkylaminethiocarbonyl)disulfides as Potent and Selective Monoglyceride Lipase Inhibitors

  摘要：

  Monoglyceride lipase (MGL) inhibition may offer an approach in treating diseases in which higher 2-arachidonoyglycerol activity would be beneficial. We report here the synthesis and pharmacological evaluation of bis(dialkylaminethiocarbonyl)disulfide derivatives as irreversible MGL inhibitors. Inhibition occurs through interactions with MGL C208 and C242 residues, and these derivatives exhibit high inhibition selectivity over fatty acid amide hydrolase, another endocannabinoid-hydrolyzing enzyme.

  DOI：

  10.1021/jm901323s
• 作为产物：
  描述：

  二硫化碳 、 2,6-二甲基哌啶 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 1.0h， 生成 potassium;2,6-dimethylpiperidine-1-carbodithioate
  参考文献：
  名称：

  Synthesis and antifungal activity of new carbamodithioic acid esters derived from 3-acetylcoumarin

  摘要：

  DOI：

  10.1016/0223-5234(96)89561-4

文献信息

• Synthesis and Antimicrobial Activity of {2-[2-(N, N-disubstituted thiocarbamoyl-sulfanyl)-acylamino] thiazol-4-yl}acetic Acid Ethyl Esters
  作者：Öznur Ateş、Aysel Gürsoy、Handan Altıntaş、Gülten Ötük、Seher Birteksöz

  DOI：10.1002/ardp.200390002

  日期：2003.3

  2‐[2‐(N, N‐Disubstituted thiocarbamoyl‐sulfanyl)acylamino ]thiazol‐4‐yl}acetic acid ethyl esters (3a—x) were synthesized by the reaction of potassium salts of N, N‐disubstituted dithiocarbamoic acids with [2‐(2‐chloroalkanoyl)amino‐thiazol‐4‐yl]acetic acid ethyl esters. The structures of the synthesized compounds were confirmed by elemental analyses, UV, IR, 1H‐NMR, and EI mass spectral data. The

  2-[2-(N,N-二取代硫代氨基甲酰基-硫烷基)酰氨基]噻唑-4-基}醋酸乙酯(3a-x)是通过N,N-二取代二硫代氨基甲酸的钾盐与[2-(2-氯代烷酰基)氨基-噻唑-4-基]乙酸乙酯。通过元素分析、UV、IR、1H-NMR和EI质谱数据确认合成化合物的结构。使用Mueller-Hinton肉汤和Mueller-Hinton琼脂通过微量肉汤稀释技术研究所有化合物的抗微生物活性。在本研究中，金黄色葡萄球菌 ATCC 6538、表皮葡萄球菌 ATCC 12228、大肠杆菌 ATCC 8739、肺炎克雷伯菌 ATCC 4352、铜绿假单胞菌 ATCC 1539、伤寒沙门氏菌、弗氏志贺菌、奇异变形杆菌 ATCC 14153 和白色念珠菌 ATCC10231 用作测试微生物。被测化合物3a、d、e、f、h、k、w对表皮葡萄球菌ATCC 12228的活性（MIC：156mg/L、78mg/L、62
• Synthesis of Some Substituted Carbamodithioic Acid Esters and Their Anticholinergic Properties
  作者：Cihat Safak、Hakkl Erdo??an、Mevlüt Ertan、Rümeysa Sunal

  DOI：10.1002/ardp.19883211207

  日期：——

  5‐chloro‐3‐methyl‐6‐(2‐bromopropionyl)‐2‐benzoxazolinone and substituted potasium dithiocarbamate derivatives. Their structures have been elucidated by UV‐, IR‐, and NMR‐spectra and by elemantary analysis. The title compounds have been assayed for their antispasmodic activity on guineapig ileum, they possess spezific anticholinergic properties.

  通过 5-氯-3-甲基-6-(2-溴丙酰基)-2-苯并恶唑啉酮和取代的二硫代氨基甲酸钾衍生物反应制备了八种新的二硫代氨基甲酸酯。它们的结构已通过紫外、红外和核磁共振光谱以及元素分析阐明。已测定标题化合物对豚鼠回肠的解痉活性，它们具有特定的抗胆碱能特性。
• Some New Carbamodithioic Acid Esters
  作者：Hakki Erdo??an、Cihat Şafak、Erhan Palaska、Mevlüt Ertan、Rümeysa Sunal

  DOI：10.1002/ardp.19883211224

  日期：——

  Twelve new dithiocarbamates have been prepared by the reaction of α‐bromo‐2′‐acetonaphthone and substituted potassium dithiocarbamate derivatives. Their structures have been elucidated by UV‐, IR‐ and NMR‐spectra and by elementary analysis. The title compounds have been assayed for antispasmodic activity on guinea pig ileum, they possess specific anticholinergic properties.

  通过α-溴-2'-乙酰萘与取代的二硫代氨基甲酸钾衍生物反应制备了12种新的二硫代氨基甲酸酯。它们的结构已通过 UV、IR 和 NMR 光谱以及元素分析阐明。已测定标题化合物对豚鼠回肠的解痉活性，它们具有特定的抗胆碱能特性。
• Palaska; Sarac; Safak, Arzneimittel-Forschung/Drug Research, 1992, vol. 42, # 12, p. 1453 - 1455
  作者：Palaska、Sarac、Safak、Erdogan、Erol、Alpan

  DOI：——

  日期：——
• Safak; Erdogan; Yesilada, Arzneimittel-Forschung/Drug Research, 1992, vol. 42, # 2, p. 123 - 126
  作者：Safak、Erdogan、Yesilada、Erol、Cimgi

  DOI：——

  日期：——